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Portail > Offres > Offre UMR8612-SIMMUR-014 - Post doc_24 mois_hydrogels hybrides injectables comme stratégie innovante pour le traitement de l'ostéoarthrite (H/F)

post doc_24 moisinjectable hybrid hydrogels as an innovative strategy for the treatment of osteoarthritishydrogels hybrides injectables comme stratégie innovante pour le traitement de l'ostéoarthrite (H/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mardi 7 février 2023

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General information

Reference : UMR8612-SIMMUR-014
Nombre de Postes : 1
Workplace : ORSAY
Date of publication : Tuesday, January 17, 2023
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 3 April 2023
Proportion of work : Full time
Remuneration : Between €2889 and €4082 gross per month depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

The post-doc will work on the construction and characterization of a hybrid system capable of ensuring a controlled and sustained release of active molecules into the intra-articular cavity.
This system will combine a hydrogel matrix with controlled porosity and nanoparticles loaded with active molecules. The characteristics of this system can be easily modulated by adjusting the properties of each component.

Activities

The balance between anabolism and catabolism is essential for maintaining joint function. Its loss leads, among other consequences, to the degradation of articular cartilage, which in turn results in osteoarthritis (OA).
Treatment options are limited to symptomatic management of inflammation and pain. There is therefore an urgent need to develop treatments that can act on the progression of the disease and address their formulation.
The project leader (Dr Cailotto) and his team have recently identified and patented two peptides that induce the synthesis of the extracellular matrix of cartilage. Despite these promising results, their intra-articular (IA) administration in the clinic is compromised by their rapid removal from the joint. Thus, this project aims to develop a versatile platform for the controlled release of peptides into the joint.


Synthesis and characterisation of appropriately functionalised polymers for use as a gel matrix.
Formulation and characterisation of peptide-loaded nanoparticles.
Characterisation of the physico-chemical properties of the prepared formulations.
Analysis of the results and writing of progress reports.

Skills

The candidate must hold a PhD in polymer chemistry, physics and biomaterials chemistry or strictly related disciplines.
The candidate should have a proven record of first author publications in leading international journals.
The candidate should have strong experience and knowledge in the field of (i) design and characterization of biomaterials and hydrogels and (ii) formulation and characterization of nanomedicines.
The candidate should have experimental skills in materials characterization (DLS, DSC, FTIR, electron microscopy, NMR, rheology) and/or analytical methodologies (fluorescence, UV-Vis, SDS-PAGE, SEC, HPLC, ELISA).

The candidate must be fluent in written and spoken English.
We are looking for a candidate with a strong scientific background and motivation to solve challenging problems by actively planning, designing, executing and interpreting experiments independently.
We are looking for candidates who are willing to work in a multidisciplinary research environment, have excellent communication skills, are team players, motivated, trustworthy, critical and open-minded.

Work Context

The project is based on a collaboration between the Institut Galien Paris Saclay (http://www.umr-cnrs8612.universite-paris-saclay.fr/index.php ) and the "Molecular engineering and joint physiopathology" laboratory of the University of Lorraine in Nancy (https://imopa.cnrs.fr/fr/accueil/)
The project has been financed under the FRM call for projects on regenerative medicine.

The work of the candidate will be carried out under the supervision of Dr Simona Mura (IGPS, http://www.umr-cnrs8612.universite-paris-saclay.fr/pres_eq7.php ).

The research activity of the Institut Galien Paris-Sud (IGPS) is focused on the design, development, characterisation and preclinical evaluation of nano- or micrometer-scale systems as therapeutic and/or diagnostic tools.
The IGPS is currently composed of 6 teams and has a total staff of about 120 people (including many PhD students and post-docs). Additionally, the unit has several common service facilities available to all researchers, PhD students and post-doctoral fellows of the UMR teams, including the rheology platform.
The post-doctoral fellow will work in the new Henri Moissan building.

Constraints and risks

Not any specific risk

Additional Information

The candidate must have obtained a PhD within the last two years at the time of recruitment.
To be considered, the application must be written in English and include.
- A curriculum vitae / CV
- A letter of motivation describing relevant professional experience in relation to the qualifications required for the position and interest in the appointment.
- A detailed list of practical and theoretical skills
- A full list of publications
- At least two professional references including name, address, telephone number (mobile if applicable) and e-mail address.

Incomplete applications will not be considered.
Applications will be considered as they are received until the position is filled.
For any enquiries about the position, please send an email to Dr Simona Mura simona.mura@universite-paris-saclay.fr and Dr Frederic Cailotto frederic.cailotto@univ-lorraine.fr with the object "FRM_postdoc".

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