Faites connaître cette offre !
Reference : UMR8612-JULNIC-002
Workplace : CHATENAY MALABRY
Date of publication : Monday, July 19, 2021
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 September 2021
Proportion of work : Full time
Remuneration : ~3k€ net / month
Desired level of education : 5-year university degree
Experience required : 1 to 4 years
In the field of biomaterials, synthetic biodegradable polymers are mainly limited to two categories: polyesters (e.g., polycaprolactone, polylactide, polyglycolide and their copolymers) and polypeptides. However, there are many drawbacks and limitations to the synthesis of well-defined and functionalized polymers (e.g., complex synthesis, low structural and compositional diversity, difficult functionalization, etc.). Allowing the degradation of vinyl polymers appears to be a major challenge. In this spirit, the idea is to copolymerize a traditional vinyl monomer with a cyclic ketene acetal (CKA) comonomer, which is a precursor of biodegradable ester functions, via a radical ring-opening polymerization (rROP) mechanism. In this case, rROP has both the advantages of ring-opening and radical polymerization, and thus allows the radical synthesis of well-defined biodegradable copolymers with ester functions in the polymer backbone.
This project will attempt to diversify the families of degradable vinyl copolymers by copolymerizing various vinyl monomers with CKAs of varying structures, with a view to industrial use
Synthesis of degradable vinyl polymers by radical ring-opening polymerization
Characterization of the polymers
Essential skills in controlled radical polymerization and ring-opening radical polymerization
Essential skills in polymer characterization (SEC, NMR)
The project is based on a collaboration between the Institut Galien Paris Saclay and SNF
The person recruited will be under the supervision of Dr. Julien NICOLAS
Constraints and risks
No particular constraints or risks
We talk about it on Twitter!