Informations générales
Intitulé de l'offre : New Antibody's format: strategies to evaluate their aggregation propensity for better developability (M/W) (renewable once) (H/F)
Référence : UMR8612-CLASMA-002
Nombre de Postes : 1
Lieu de travail : ORSAY
Date de publication : mercredi 25 octobre 2023
Type de contrat : CDD Scientifique
Durée du contrat : 12 mois
Date d'embauche prévue : 4 décembre 2023
Quotité de travail : Temps complet
Rémunération : 2889,51-4082,90 euros per month depending on experience
Niveau d'études souhaité : Niveau 8 - (Doctorat)
Expérience souhaitée : 1 à 4 années
Section(s) CN : Physical chemistry, theoretical and analytic
Missions
The project's ambition is to create new antibody formats adapted to alternative routes of administration compared to the traditional ones (i.v. or subcutanneous), in particular, the inhalation one. To achieve this goal, the post-doc will develop analytical based strategies to elucidate aggregation susceptibility of various mAbs and to predict antibody stabilities when administered with new routes of administration. The impact of the degraded forms on innate immunity cells will also be investigated in vitro in close collaboration with the consortium partners.
Activités
New mAbs of different formats (Multispecific, ADC, …) will be produced by our partners using inovative engineering processes. Their degradation/aggregation pathways (under different stresses) will be thoroughly investigated (sub-unit involved,….). The impact of the formulations allowing the different routes of administration will also be evaluated.
Compétences
Analytical chemist interested by cell biology and Immunology. knowledge on mAbs/proteins analysis.
Contexte de travail
This postdoc is part of the large project ACCREDIA bringing together a network of industrial and academic partners funded by the French government aiming at improving the knowledge, skill, and methodologies in antibody developability.
Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.