Informations générales
Intitulé de l'offre : Postdoctoral fellow (M/F) in organic synthesis of porphyrin conjugates (H/F)
Référence : UMR8612-ALIMAK-005
Nombre de Postes : 1
Lieu de travail : ORSAY
Date de publication : jeudi 24 juillet 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 18 mois
Date d'embauche prévue : 1 octobre 2025
Quotité de travail : Complet
Rémunération : starting from 3081 € gross per month depending on the experience
Niveau d'études souhaité : Doctorat
Expérience souhaitée : 1 à 4 années
Section(s) CN : 16 - Chimie du vivant et pour le vivant : conception et propriétés de molécules d'intérêt biologique
Missions
- Synthesis of new conjugates and their chemical characterization (NMR, Mass spectrometry)
- Preparation of their supramolecular assemblies and characterization by DLS, TEM, absorbance, fluorescence, stability, etc…
- Evaluation of their photothermal/photodynamic efficicencies against plactonic bacteria and biofilm
Activités
1. Define a work program and carry out the experiments
2. Writing and preparing publications/posters/oral presentations
3. Participate to the common laboratory tasks
4. Participate the supervision of trainees and doctoral students
Compétences
PhD in organic or medicinal chemistry or materials chemistry with experience in the synthesis of porphyrins and/or their derivatives.
Contexte de travail
Photothermal therapy (PTT) and photodynamic therapy (PDT) that rely on the generation of heat and reactive oxygen species upon the illumination of photoactive materials have emerged as promising antimicrobial approach for localized resistant bacterial infections. Since many years, our team is developing light-responsive nanomaterials based on the assemblies of Lipid-Porphyrin conjugates to combat either local resistance bacterial infections or solid tumors. These assemblies showed good therapeutic outcomes, however there are still some room of improvement mainly by reducing their photothermal effect compared to their photodynamic efficiency. Therefore, the aim of this project is to develop breakthrough assemblies based on the synthesis of smart porphyrin-lipid conjugates thus enabling bimodal and tunable PTT/PDT to combat efficicently resistant bacteria and biofilm related infections without the need of antibiotics. This postdoc offer is part of the PHORTUNA project of PEPR LUMA research programme (light-matter interactions) and was supported by the French National Research Agency, as a part of the France 2030 program, under grant ANR-24-EXLU-0011.
Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.
Contraintes et risques
No particular constraints.