Missions

The team is developing polymeric hollow nano-transporters for CRISPR-Cas9 gene editing. In preliminary experiments, we demonstrated that the unoptimized transport system is capable of encapsulating the CRISPR/Cas9 complex and introducing it into cultured human cells. As the main aim of this project is to deliver large RiboNucleoProtein complexes and plasmid DNAs to human neuronal cells, in particular retinal cells, it will produce a conceptually new and safe transfection family for ex vivo / in vivo gene replacement therapy.

Activités

Design and synthesis of novel “smart” nano-systems; Characterization of organic compounds using standard analytical methods (NMR, MS, chromatography) and biological evaluations (confocal and fluorescence imaging, cell cytometry, bio-stat etc.); Ability to communicate in a multidisciplinary environment;

Compétences

Ph.D. in Organic Chemistry; Strong background in synthetic organic chemistry, with expertise in cellular biology being advantageous; Proficiency in modern synthetic techniques and analytical methods; Demonstrated track record of productivity through publications and presentations; Ability to work both independently and collaboratively in a dynamic research environment; Ability of communicating / writing research papers.

Contexte de travail

A highly interdisciplinary and international environment at the Faculty of Medicine in central Paris