Postdoctoral researcher (M/F) in bioorganic chemistry / chemical biology
New
- Researcher in FTC
- 18 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
75270 PARIS 06
Contract Duration
18 months
Date of Hire
04/01/2027
Remuneration
starting at 3131 € gross monthly salary, depending on experience
Apply Application Deadline : 17 November 2026 23:59
Job Description
Missions
The postdoctoral researcher will be involved in a multidisciplinary research project aimed at developing the synthesis of polyazamacrocyclic compounds as ligands for non-canonical nucleic acid structures (including DNA three-way junctions) with anticancer applications, and at functionalizing them for applications in chemical biology.
Activity
- Organic synthesis and molecular characterization.
- Participation in chemical biology experiments (in collaboration with a partner team).
Your Profil
Skills
- Strong experience in organic chemistry, preferably in the chemistry of macrocyclic compounds and/or heterobifunctional molecules.
- Proficiency in molecular characterization techniques (NMR, MS, HPLC).
- Basic knowledge of nucleic acid biochemistry, molecular biology, and/or chemical biology.
- Organizational and adaptability skills.
- Excellent command of English (written and oral comprehension, protocol and article writing).
- Monitoring the evolution of hygiene and safety regulations and ensuring their application in coordination with the Prevention Assistant.
Your Work Environment
The proposed position is part of a multidisciplinary project funded by AVIESAN and dedicated to the development, optimization, and functionalization of ligands targeting DNA three-way junctions for cancer treatment, as well as the development of chemical tools to study their mechanisms of action in cellulo. This project is conducted in collaboration with teams from the Institut de Pharmacologie et de Biologie Structurale (Toulouse) and Université Bourgogne Europe (Dijon).
The host team, "New Synthetic Methods for the Chemistry-Biology Interface," is part of the CNRS UMR8601 unit "Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques," located at Université Paris Cité (Paris 6th arrondissement). The team's research spans a broad range of topics in synthetic organic chemistry and chemical biology, all grounded in molecular innovation. Our work involves exploring new chemical spaces, as well as developing synthetic tools or analytical methods to study and/or interfere with biological regulatory mechanisms.
Constraints and risks
The position involves exposure to chemical and biological risks, which will be managed in accordance with national regulations and the laboratory's internal rules.
Compensation and benefits
Compensation
starting at 3131 € gross monthly salary, depending on experience
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR8601-ANTGRA-005 |
|---|---|
| CN Section(s) / Research Area | Chemistry of and for life: design and properties of molecules of biological interest |
| Relevant experience | 1 to 4 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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