General information
Offer title : Researcher in organic chemistry (M/F) - Novel photocaged protecting groups for the preparation of peptides of biological interest (H/F)
Reference : UMR8531-NICBOG-002
Number of position : 1
Workplace : ST AUBIN
Date of publication : 01 October 2024
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 13 January 2025
Proportion of work : Full time
Remuneration : between 3081 and 3519 € gross monthly
Desired level of education : Niveau 8 - (Doctorat)
Experience required : 1 to 4 years
Section(s) CN : Chemistry of and for life: design and properties of molecules of biological interest
Missions
The aim of this project is to develop a new method for the side-chain functionalization of cyclic peptides based on sequential, wavelength-selective photo-deprotection reactions.
Activities
The recruited researcher will be responsible for designing and preparing (by multi-step synthesis) photocaged amino acids, assembling them into cyclic peptides by solid-state synthesis, and evaluating their photophysical properties, in particular their ability to be selectively deprotected depending on the irradiation wavelength applied.
Skills
Solid experience in multi-step organic synthesis, as well as a marked interest in bioorganic chemistry. Background in photophysics/photochemistry and/or peptide synthesis is not mandatory but would be an asset.
Work Context
This ANR-funded project (DynaCycloP) is part of a collaboration with partner laboratories at Sorbonne Université (Laboratoire des Biomolécules), Université de Montpellier (Institut des Biomolécules Max Mousseron) and Université d'Orléans (Institut de Chimie Organique et Analytique).
Mobility to Sorbonne Université (Paris) is planned for the realization of peptide synthesis.