General information
Offer title : Post-Doc (M/F) (H/F)
Reference : UMR8516-GIUSIC-002
Number of position : 1
Workplace : VILLENEUVE D ASCQ
Date of publication : 31 December 2025
Type of Contract : Researcher in FTC
Contract Period : 18 months
Expected date of employment : 2 March 2026
Proportion of work : Full Time
Remuneration : Between 3131,32 € and 3569,85 €
Desired level of education : Doctorate
Experience required : Indifferent
Section(s) CN : 12 - Molecular architectures: syntheses, mechanisms and properties
Missions
The postdoc will realize an EPR analysis on DNA-based enzymes, using 1D and 2D techniques. Two main systems will be investigated, having Copper(II) and Manganese(II) as metal co-factor. Structural and mechanistic features will be deciphered in order to fully understand the cleavage reaction of DNA with DNAzymes.
Activities
Sample preparation (DNA both as catalyst and substrate), followed by optimization of pulsed EPR sequences. Those experiments must indeed be tailored to the above mentioned architectures, in order to identify short and long range interactions.
Skills
Knowledge of magnetic resonance principles, with a particular focus on pulsed EPR methods. Basic knowledge on homogeneous catalysis will be a plus.
Work Context
The project will be carried out at LASIRE, as member of the team 'Structural and Magnetic Properties of Materials. Four EPR spectrometers are available, in addition to three laboratories where sample preparation can be realized.
The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.
Constraints and risks
Mainly aqueous buffer solutions will be analyzed, without particular risks to highlight.