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Portal > Offres > Offre UMR8258-CELHOF-001 - Post-doctorant (H/F) « Identification de cibles thérapeutiques potentielles pour la fibrose hépatique »

Postdoctoral fellow (W/M) - Identification of potential therapeutic targets for liver fibrosis

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Français - Anglais

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General information

Reference : UMR8258-CELHOF-001
Workplace : PARIS 06
Date of publication : Monday, September 09, 2019
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 November 2019
Proportion of work : Full time
Remuneration : Between 2600 and 3800 euros/month before charges according to experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

The objective of the post-doctoral fellow will be to identify potential therapeutic targets for inhibiting hepatic fibrosis by siRNA vectors.
In a first step, the study of the expression of proteins and cytokines, expected as overexpressed during the fibrogenesis process and of interest for its resolution, will be carried out on a metabolic liver fibrosis mouse model.
In parallel, a transcriptomic study of the murine model will be conducted to characterize new markers of metabolic liver fibrosis that could be new targets for siRNA inhibition.
Target identification will be challenged by comparing the results obtained on the in vivo model, to human samples of patients presenting liver fibrosis.

Activities

- Biochemistry and molecular biology experiments (quantitative PCR (qPCR, ddPCR), Western Blot, Elisa ...)
- Cell culture, transfection
- Analysis of transcriptomic data, statistical analyzes
- Written and oral communication of scientific results

Skills

- Depth knowledge of biochemistry, cell and molecular biology techniques
- Knowledge of classical molecular biology computer tools and office tools
- Knowledge in sequencing data analysis and statistical tests would be a plus
- Implementation and management of a research project
- Writing scientific articles skills

Work Context

The proposed postdoctoral contract is part of a Young Researcher project "Fibrother - Multiplexed nanovectors for liver fibrosis therapy" funded by the French Research National Agency.
The post-doc recruited will be welcomed in the "Biotherapy" team of the UTCBS, led by Dr. Virginie Escriou and the work will be done under the direction of Dr. Celine Hoffmann. The team involved in the project is multidisciplinary (biologists, chemists and pharmacists) and composed of researchers, a doctoral student and hospital practitioners. The postdoc project also involves the biostatistician team from the Faculty of Pharmacy.

Constraints and risks

N/A

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