Post doctoral position (M/F)
New
- Researcher in FTC
- 12 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Plasticité du cerveau
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
75231 PARIS 05
Contract Duration
12 months
Date of Hire
01/01/2027
Remuneration
3131
Apply Application Deadline : 11 November 2026 23:59
Job Description
Missions
Effects of artificial KCC2 clustering on intracellular chloride regulation in hippocampal interneurons and pyramidal cells, and on epileptic activity
Activity
We will develop super-resolution imaging and single-molecule tracking of KCC2 in interneurons and pyramidal cells in mouse hippocampal slices or human epileptic tissue.
After characterizing and comparing the membrane distribution and mobility of KCC2 in interneurons and pyramidal cells, we will determine the impact of antibody-induced artificial KCC2 clustering.
We will then investigate the functional impact of this strategy using electrophysiology (patch-clamp recordings of EGABA and multielectrode array (MEA) recordings of network activity) in human epileptic tissue slices.
Your Profil
Skills
• Neurosciences
• Electrophysiology and super-resolution imaging
• Autonomy
• Ability to work effectively as part of a team
• Ability to regularly report results and progress to the line manager
Your Work Environment
The successful candidate will join the La Synapse Dynamique team, led by Sabine Lévi and based in the Brain Plasticity Unit (UMR 8239) at ESPCI Paris. Our research focuses on the cellular and molecular mechanisms underlying the stabilization of nascent synapses during development and the plasticity of mature synapses, with a particular emphasis on hippocampal GABAergic synapses. We use single-molecule imaging techniques, including single-molecule tracking in live neurons and super-resolution STORM/PALM microscopy.
Compensation and benefits
Compensation
3131
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR8249-SABLEV-003 |
|---|---|
| CN Section(s) / Research Area | Molecular and cellular neurobiology, neurophysiology |
| Relevant experience | 1 to 4 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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