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Reference : UMR8249-PIEPLA-002
Workplace : PARIS 05
Date of publication : Monday, April 12, 2021
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 3 May 2021
Proportion of work : Full time
Remuneration : 33-47 k€/year gross salary (depending on experience)
Desired level of education : PhD
Experience required : 1 to 4 years
A postdoctoral position is available in our research group “Energy & Memory”, located in the Brain Plasticity Department at ESPCI, Paris, and part of PSL Research University. Come and join our team in the lively historic center of Paris, which hosts a large and dynamic neuroscience research community !
Our group has developed over the past years a specific expertise in studying the relationships between energy metabolism and plasticity mechanisms underlying memory. We work on Drosophila, as fruitflies feature both sophisticated memory dynamics following associative conditioning, and a relative simplicity in brain circuits that, in combination with powerful genetic tools, allows the finest dissection of the underlying circuits and molecular mechanisms. One of our core expertise is the development of innovative approaches to monitor in vivo brain energy fluxes by 2-photon imaging, which allowed in the recent past revealing crucial metabolic regulations following conditioning in the mushroom bodies, the memory center in the insect brain. For instance, we showed that increased pyruvate consumption by mitochondria in mushroom body neurons gates the formation of long-term memory (Plaçais et al., 2017). We also investigate the neuron-glia metabolic coupling underlying memory (de Trédern et al., in preparation).
We aim at characterizing the age-induced metabolic alterations within the Drosophila brain memory center, and at linking regional specificities in energy metabolism with memory's vulnerability to aging.
- 2-photon and FLIM in vivo imaging on Drosophila
- Behavioral experiments (olfactory conditioning)
- Autonomous project management (elaboration of experimental strategies)
- Interaction with collaborators (optics, image analysis)
- Optional: student supervision
To tackle this project, which involves dedicated collaborations with local and international groups in optics, image analysis and neurobiology, we are looking for a postdoctoral fellow with experience in energy metabolism and/or Drosophila neurobiology. Candidates with a strong background in 2-photon or FLIM imaging willing to engage into neurobiology applications are also welcome to apply.
Our lab, hosted in spacious new premises, accomodates five climate chambers for behavior experiments, and two multiphoton imaging stations on its own, including a cutting-edge 2-photon FLIM microscope
Starting date is flexible (immediate start possible).
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