Missions

The candidate will participate in the INSERM PCSI project (Magneto-ultrasonic locoregional inhibition of cancer stem cells for tumor treatment) and will be responsible for preparing magnetic liposomes containing anticancer molecules and optimizing their release under focused ultrasound in vitro.

Activités

Synthesis of magnetic liposomes by different methods
Titration of encapsulated drugs
Physicochemical and physical characterizations
Monitoring of passive and stimulus-induced release of drugs

Compétences

Candidates must hold a PhD in chemistry or pharmacology with a focus on formulation. Expertise in the formulation of liposomes or lipid nanoparticles will be appreciated. The candidate should be proactive in suggesting methods for encapsulating anticancer molecules, with the potential to consider large-scale production. The candidate will need to interact with the biologist partners at the Curie Institute responsible for in vivo experiments.

Contexte de travail

The candidate will work at the PHENIX laboratory at Sorbonne University (Paris). The role of the PHENIX laboratory in this project is to prepare magnetic liposomes (a well-established expertise) co-encapsulating cytotoxic molecules. The task will be to propose methods for encapsulating the molecules based on their physicochemical properties, as well as to consider large-scale production methods. The second task will be to evaluate the release of the encapsulated molecules upon ultrasound stimulation. This work is part of a collaboration with a team of the Curie Institute expert in the study of mechanical impact on cancer development (mechanobiology) and the biomedical imaging laboratory (BioMaps) at Paris-Saclay, which is an expert in the development of ultrasound instrumentation.