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Portail > Offres > Offre UMR8227-JERCOC-003 - Post-doctorat génétique algue brune (H/F)

Postdoctoral fellowship in brown algal molecular genetics (H/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : lundi 15 août 2022

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General information

Reference : UMR8227-JERCOC-003
Workplace : ROSCOFF
Date of publication : Monday, July 25, 2022
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 October 2022
Proportion of work : Full time
Remuneration : Between 3069€ and 3783€ per month depending on the level of experience of the candidate
Desired level of education : PhD
Experience required : Indifferent

Missions

Life cycles play a key role in determining many features of an organism's biology. The diverse life cycles of the brown algae strongly influence ecological and developmental characteristics and, from an applied point of view, the capacity to control the life cycle is essential for successful aquaculture production of brown seaweeds. The host laboratory has recently identified two master life cycle regulators, the TALE homeodomain transcription factors OUROBOROS and SAMSARA, and has developed several new tools to investigate life cycle regulation, including CRISPR-Cas9-based gene knockout methodology. The objective of the postdoctoral project will be to further investigate the mode of action of OUROBOROS and SAMSARA and to identify and characterise additional life-cycle-related processes using molecular genetic approaches, particularly analysis of mutant lines generated using the recently developed CRISPR-Cas9 methodology. The project is financed by the French National Research Agency project "Epicycle".

Activities

The project will involve maintenance and growth of wild type and mutant Ectocarpus strains, application of CRISPR-Cas9 methodology to generate new mutant lines and phenotypic characterisation of both existing (in particular the ouroboros and samsara mutants) and newly created mutant lines. Phenotyping will potentially employ a range of different approaches including morphometry, cell biology approaches, transcriptomic and epigenetic approaches. Protocols are available in the host laboratory for all these approaches.

Skills

The candidate should have experience with standard molecular biology and cell biology (microscopy) approaches. Standard bioinformatic skills, for example the capacity to handle transcriptomic data, would be useful and experience working with CRISPR methodology and/or handling brown algae in culture would also be appreciated.

Work Context

The postdoctoral fellowship will be in the Algal Genetics Group (Department "Integrative Biology of Marine Models" UMR8227) at the Station Biologique de Roscoff.
The host institute, the Station Biologique de Roscoff, is a marine biology and oceanology research centre situated in the town of Roscoff on the beautiful north coast of Brittany.

Constraints and risks

Standard risks associated with work in a molecular biology laboratory

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