Faites connaître cette offre !
Reference : UMR8214-RUXGRE-002
Workplace : ORSAY,ORSAY
Date of publication : Monday, September 28, 2020
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 4 January 2021
Proportion of work : Full time
Remuneration : around 54854 E/year
Desired level of education : PhD
Experience required : Indifferent
Post-doctoral position for one year (possibility for prolongation). We are looking for a highly motivated candidate able to work in a competitive, topic at the fronteer between chemistry, nanotechnology and biology. The project is supported by the "Laboratory of Excellence NanoSaclay". The work will be carried on in the exceptional scientific environment of Paris-Saclay University ans associates four teams: located in Institut des Sciences Moléculaires d'Orsay (ISMO), l'Institut de Chimie Physique (ICP), Laboratoire de Physique des Solides (LPS), and Laboratoire METSY in Institut Gustave Roussy.
The interdisciplinary project aims to develop a new therapeutic approach against hormone-resistant prostate cancers, the most aggressive form of this pathology still lacking of effective clinical treatments. Our hypothesis is to use hybrid nanosized MOFs (Metal organic framework) as a double-edged sword able to protect and improve the biodisponibility of the anticancer drug and to increase its selectivity for cancer cells. Optimizing these nanosystems with a therapeutic objective involves controlling their physicochemical properties and composition using quantitative nanotools at the single particle level and evaluating their anticancer activity on cellular and pre-clinical models. This interdisciplinary project combines chemical, physical and biological aspects which will be tackled by a team. Optimized synthesis, drug entrapment, surface modification and comprehensive characterization may lead to a new therapeutic approach for patients with cancers and refractory to hormone therapy.
In a first step, hybrid nanoparticles will be synthesized and surface-modified, then comprehensively characterized by a set of complementary methods to determine their morphology, size distribution, stability, surface properties, interactions with biological media. Then, drug release and nanoparticle degradation will be investigated. Finally, the nanoparticle efficacy will be tested in vitro. In vivo studies will selected samples will be carried on at IGR.
Highly motivated candidate, autonomy, team spirit, ability to write scientific publications and present the work in group meetings.
Competent in HPLC, DLS, spectroscopies, microscopies, cell culture, synthesis of hybrid nanoparticles, surface modification.
The work will be carried on in the Institut de Sciences Moléculaires d'Orsay (ISMO) - UMR CNRS 8214 - Université Paris-Saclay. The team NanoBio develops nanomedecine to treat severe diseases such as resistant infections and cancer, as well as advanced superresolution microscopies. The interdisciplinary teams is composed of around 18 post-docs, PhD or master studens from different countries and with various backgrounds. The candidate will work with Dr Gref, responsible of the team. The experimental work will be essentially carried on in a dedicated room for nanoparticle preparation, with acces to common laboratories and platforms (chemistry, biology, characterizations etc) of the Institute. The team also uses various facilities at Paris Saclay University. The candidate will also have acces to the Gustave Roussy Institute.
Constraints and risks
Risks related to work in cell culture facilities. The labs are under the responsability of an Engineer .
Mobility required between the collaborating teams, located in proximity.
We talk about it on Twitter!