General information
Offer title : M/F postdoc Identification of factors involved in the template choice during mitotic interhomolog recombination in diatoms (H/F)
Reference : UMR8197-VALHER-131
Number of position : 1
Workplace : PARIS 05
Date of publication : 03 October 2024
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 January 2025
Proportion of work : Full time
Remuneration : Between 3 081€ et 4 756€ according to experience
Desired level of education : Niveau 8 - (Doctorat)
Experience required : Indifferent
Section(s) CN : Organisation, expression and evolution of genomes Bioinformatics and systems biology
Missions
Postdoctoral contract to study recombination between homologous chromosomes in diatom vegetative cells in the Phytogenomics team at The Institute of Biology of the École normale supérieure (IBENS).
In this study, we aim to understand the mechanism of the template choice for HR. The postdoctoral fellow will conduct a chemical genomic and forward genetic screening aimed at identifying the compounds and proteins/genes that interfere with the choice of the template for homologous recombination but do not affect other steps of DNA damage repair by homologous recombination. A short visit to a collaborating laboratory in Ghent, Belgium is planned for the chemical-genomic screen.
Activities
- Contribute to the characterization of read-out systems for homologous chromosome and sister chromatid recombination
- Optimize the condition for chemical genomic screening
- Perform the chemical genomic screening in collaboration with the VIB screening facility
- Perform initial characterization of selected compounds
- Contribute to forward genetic screening together with other team members
Skills
The candidate must hold a PhD or equivalent degree or must have submitted the PhD thesis for evaluation by the application deadline.
He/she/they must have a strong research background in molecular and cellular biology and the ability to think critically and understand the key concepts related to the project.
Research experience with microalgae or previous work in the field of DNA repair is welcome but not required. A high work ethic standards, and the capability to work independently while cooperating and communicating with the other group members are essential.
Work Context
The project will be conducted within the PhytoGenomics host team led by Chris Bowler (ibens.ens.fr), which offers a friendly working environment. The laboratory has a strong history in research on many aspects of diatom biology, including genomics and cell biology. Currently, the team includes 3 PhD students, 3 postdocs, 1 lecturer-researcher, 1 CNRS researcher, and 1 CNRS engineer. The team's work focuses on the mechanisms by which the environment can influence the structure and dynamics of genomes.
The Institute of Biology of the École Normale Supérieure (IBENS) is a multidisciplinary research center with an international vocation located in the Latin Quarter in the center of Paris. This joint CNRS/Inserm/ENS unit includes around 330 agents, divided into 29 research teams.
Constraints and risks
None