Missions

Study input layer cerebellar microcircuits thanks to optical methods in vivo. Investigate populational activities of Golgi cells, their communication rules and the influence of their inputs on granule cell patterning in the context of sensori-motor pattern separation

Activités

Propose working hypothesis, perform experiments and data analysis to conduct the project :
Perform viral injections and optical cranial window.
Perform chronic imaging, photostimulation and optical recordings experiments from cerebellar microcircuits neurons during behavioral tasks.
Perform quantitative data analyses using proper mathematical tools.
Scientific paper writing.

Compétences

The candidate will have performed in vivo multiphoton optical recordings or targeted patch-clamp recordings or will have performed experiments on gap junction coupled neuronal networks.
Being familiar with viral transduction and associated genetic strategies.
Must be skilled in programing (data analysis) and statistics.
Being graded with animal experimentation (conception and surgery)
Knowing basics in optic/neurophotonic.
Must be skilled in communication (English, speaking and writing) and scientific writing.
Enjoying team work.

Contexte de travail

The Institute of Biology of École normale supérieure (IBENS) is a fundamental research centre in Life sciences. Our research aims at deciphering the fundamental mechanisms at the core of biological processes.
IBENS (ENS, CNRS and Inserm joint unit) hosts over 300 people in 30 autonomous teams. The research environment is highly collaborative and interdisciplinary, and combines experimental and theoretical approaches. Our activities cover fields as various as functional genomics, neurobiology, developmental biology, ecology and evolution biology.
Several technological platforms, notably in imaging, genomics, computational biology and proteomics, provide a robust support to the activities of the different teams. Our research also benefits from the high potential of interactions with other scientific departments in ENS (physics, chemistry, mathematics, informatics, etc.). ENS is deeply involved in the formation of students and young researchers at all levels.
The host team -Inhibitory transmission and neuronal computation-- is headed by -Stéphane Dieudonné-
Our research is -to understand how inhibitory transmission is used to perform basic neuronal computations and solve tasks devoted to the brain-------------------------------