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Reference : UMR8197-NATBOI-097
Workplace : PARIS 05
Date of publication : Friday, December 31, 2021
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 April 2022
Proportion of work : Full time
Remuneration : between 2800 and 3800 € monthly gross salary according to experience
Desired level of education : PhD
Experience required : Indifferent
Responsible for neurophysiological experimentation: design and execution of biological preparations (i.e. slice, organotypic culture), virus-mediated genetic targeting, recordings (electrophysiological and optical), patterned photostimulations in collaboration with physicists and quantitative analysis of results.
The postdoctoral associate will work on a multidisciplinary (biology/physics) project relevant to motor system neuroscience that aims to perform an all optical high throughput connectivity mapping of the respiratory rhythm generator. We will seek to describe and manipulate functional connectivity dynamics along the respiratory cycle that may constrain the gain, the frequency, the re-setting or the pause of the rhythm generator.
PhD or MD/PhD with a background in neuroscience or biophysics.
An outstanding record of research and scholarly activity.
Extensive wet-laboratory experience in advanced neurophysiological techniques (Patch-clamp, Optogenetics, Calcium imaging, Viral-mediated gene targeting in animal models, Stereotactic injections) and quantitative data analysis.
Experience in presenting data at international conferences-ability to synthesize and write scientific papers.
Be imaginative, open, dynamic, collegial, strongly self-driven and well organized.
In-depth knowledge of a programing language is strongly preferred.
Experience in working with mice as a model organism is strongly preferred.
Background electrophysiology in vitro (slice, organotypic culture) is strongly preferred.
Background in motor system neuroscience, microscopy, and/or rodent behavior is preferred.
The posdoctoral associate will be affiliated to the Institute of Biology of the ENS (IBENS) a center that conducts original research aimed at deciphering the fundamental mechanisms at the heart of biological processes.
A joint ENS-CNRS-INSERM unit, IBENS is home to more than 300 people grouped into 30 autonomous teams conducting highly collaborative and multidisciplinary research that combines experimental and theoretical approaches. The research activity covers various thematic fields: Neuroscience, Developmental Biology, Functional Genomics, Ecology and Evolutionary Biology. Several technological platforms, notably in imaging, genomics, proteomics and bioinformatics are available to researchers. The research conducted at IBENS benefits from interactions with other disciplines at the ENS (physics, chemistry, cognitive sciences, mathematics). IBENS is actively involved in the training of students and young researchers at all levels.
The postdoctoral fellow will join a multidisciplinary collaborative project between Dr Gilles Fortin at the Institut de Biologie de l'Ecole Normale Supérieure (IBENS) and Dr. Valentina Emiliani at the Institut de la Vision (IdV), two nearby research institutes in central Paris. Dr. Fortin has extensive experience in the genetic manipulation of developing respiratory neuronal ensembles and in manipulation of neural activity in mouse embryos and neonates. Dr Emiliani has established an advanced 2-photon light-shaping and imaging optogenetic platform allowing optical control of neuronal firing in defined neuronal sub-populations with millisecond temporal, and single-neuron spatial, resolutions. The postdoctoral associate is expected to bridge strengths from both labs and through “reading” and “writing” neural activities unveil regularities about permanent rhythm generation and modulation. The candidate is expected to lead the project and will be co-mentored by Dr. Gilles Fortin and Dr. Valentina Emiliani. The experimental work will be performed on both sites.
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