Missions

The candidate will be responsible for synthesising and characterising new nucleosides with bioorthogonal motifs that enable post-functionalisation with fluorogenic probes.

Activités

- The project aims to develop innovative functionalizations of nucleosides and oligonucleotides that will ultimately enable the chemical functionalization of these compounds in a cellular context. - Part of the project will be devoted to developing synthetic access to nucleosides functionalised with bioorthogonal motifs allowing post-functionalisation with innovative fluorogenic probes, which will also need to be prepared. - Once the strategy has been validated at the monomer level, it will be implemented at the oligonucleotide level. - The candidate will be responsible for the organic synthesis of modified nucleosides, their characterisation and establishing their conditions of use.

Compétences

- Very good knowledge of organic chemistry and training in synthetic chemistry
- Interest in the chemistry-biology interface and chemistry for living organisms
- Keeps up with the literature, enjoys multidisciplinary work
- Organised, independent, good communication skills, team player

Contexte de travail

The work will take place at the Institute of Molecular Chemistry and Materials in Orsay, Paris Saclay University. It will be carried out within the 'Synthesis of Molecules and Macromolecules for Life and the Environment' team.
The successful candidate will benefit from a stimulating scientific environment and will have access to the unit's and institute's equipment and technical facilities necessary for the project.
The position is based at the Saclay campus (91), Henri Moissan Building (BPC: Biology-Pharmacy-Chemistry).

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.