(M/F) Engineer in mass spectrometry

Job Description

Missions

Management of MALDI-TOF mass spectrometry systems, their operating environment and associated projects

Activity

• Day-to-day maintenance of equipment to optimise uptime.
• Calibration of instruments to ensure accuracy and repeatability.
• Management of consumables and maintenance contracts.
• Development of analytical methods (including fragmentation) for a wide variety of molecule families and in complex matrices.
• Data processing and report writing in both French and English.
• Training and supporting platform users, in both French and English.
• Conducting scientific and technical monitoring to be able to:
o Propose future investments to supplement and improve the system (plates, matrices, etc.)
o Build a library of methods (preparation, analysis, data processing) tailored to the diversity of the platform's projects.
• Integration of equipment into the rest of the REALCAT robotic platform:
o Implementing robotic sample preparation processes using pipetting stations, for example.
o Implement characterisation processes combining the platform's other analytical techniques to supplement the characterisation data obtained (UPLC-HRMS, HT-FT-IR, CHNOS, RAMAN, ICP-OES, XRD, XRF, etc.)

Your Profil

Skills

- Expertise in MALDI-TOF mass spectrometry
- Project management
- Teamwork
- English: minimum B2 level

Your Work Environment

WP5 of the CPER BiHautEcoAgro project focuses on biocatalysis and advanced multi-criteria analysis of chemical and biological compounds derived from the valorisation of natural resources. Its aim is to cover a wide range of topics, including sustainable production, the processing of natural resources, the chemistry of bio-based molecules and materials, the environment and ecology, as well as associated industrial safety issues.
The REALCAT equipment team specialises in the development, characterisation, measurement and performance optimisation of biological, chemical and hybrid catalysts using high-throughput methods. As part of WP5, the platform has been allocated MALDI mass spectrometers (an Autoflex MaX and a Sirius MBT from Bruker) to further enhance its analytical capabilities. The platform is currently lacking an expert in this field to manage all aspects relating to their use, maintenance and integration, as well as user training and the management of maintenance contracts and consumables. High-throughput operations require the platform's instruments to work in tandem to avoid any bottlenecks in terms of speed. This means that mass spectrometry must be used in combination with other analytical methods and/or with sample preparation robots.

The analyses carried out are very varied due to the diversity of the research projects conducted on the platform – whether academic or industrial – and thus cover numerous families of molecules (metabolites, peptides, proteins, biological or petroleum-derived polymers, etc.) as well as the identification of microorganisms (BioTyping). The matrices in which these molecules are found at the end of reactions are often complex and require optimisation of sample preparation, deposition methods and the choice of MALDI matrix, as well as the instrument's acquisition parameters.

Constraints and risks

- No specific restrictions
- Risks inherent in working in a chemistry/biology laboratory

Compensation and benefits

Compensation

gross salary from 2521,95€ depending on experience

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions