Missions

The agent will be responsible for size-based separation and characterization of sub-populations within cellular secretomes, and for assessing their regenerative and immunomodulatory properties. In particular, he/she will develop the AF4 (Asymmetrical Flow Field-Flow Fractionation) method coupled with MALS, DLS, UV-Vis, RI, and fluorescence detectors.

Activités

Bioproduction of extracellular vesicles and hybrids
Separation and analysis by AF4 of cellular secretomes
Multimodal characterization of biological nanovectors

Compétences

PhD
Nanomedicine- Bioproduction - Soft Matter physics- AI- Molecular and cellular biology - Hydrodynamic - Bioengineering

Contexte de travail

The new multidisciplinary unit NABI (Nanomedicine, Extracellular Biology, Integratome and Health Innovations), located on the Saint Germain Campus of Université Paris Cité (45 rue des Saints Pères, 75006 Paris), was established on January 1, 2025. It brings together around 70 collaborators—including physicists, biologists, pharmacists, engineers, and physicians—of which about thirty are permanent staff, under the joint supervision of CNRS, INSERM, and Université Paris Cité.

NABI's scientific objectives are to develop new therapies based on biological nano-objects (extracellular vesicles) or synthetic nano-objects (activatable metallic nanoparticles) for the delivery of personalized treatments for hard-to-treat diseases.

Studying nano-objects in biological fluids requires transdisciplinary approaches (physics, engineering, cell and molecular biology, immunology, etc.) extending all the way to clinical practice, as well as dedicated technical and analytical resources (super-resolution microscopy, nanosensors, microfluidics, etc.), combined with systematic multimodal and multiscale exploration supported by AI-driven analysis.

These innovative methodologies are developed within NABI and in partnership with the industrial integrator IVETh, a technology hub dedicated to the characterization, bioproduction, and engineering of extracellular vesicles and nanovectors for diagnostics and personalized therapies. The agent will join the multidisciplinary “Nanobiotherapies” team as part of the STROMAEV PEPR project.

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.

Informations complémentaires

This position is located in a sector covered by the protection of scientific and technical potential (PPST) and therefore requires, in accordance with the regulations, that your arrival be authorized by the competent authority of the MESR.