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Portail > Offres > Offre UMR8030-CATCON-001 - Recrutement postdoctorant en bioinformatique: Etude des programmes de régulation des gènes lors du développement des cellules CAR-T (H/F)

Postdoctoral opportunity in bioinformatics (H/F): gene regulatory programs driving CAR-T cell development

This offer is available in the following languages:
Français - Anglais
Date Limite Candidature : lundi 22 août 2022

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General information

Reference : UMR8030-CATCON-001
Workplace : EVRY COURCOURONNES
Date of publication : Monday, August 1, 2022
Type of Contract : FTC Scientist
Contract Period : 36 months
Expected date of employment : 1 September 2022
Proportion of work : Full time
Remuneration : Between 2743 - 3161 euros gross per month depending on experience
Desired level of education : PhD
Experience required : Indifferent

Missions

Missions
The postdoctoral position falls within an EU-funded collaborative project T-Fitness, to develop more resistant CAR-T cells in the context of solid tumors. The postdoctoral fellow will contribute to this project by the analysis of functional genomics data generated by the consortium, as well as by the development of computational solutions having a broader application, notably the exploitation of publicly available datasets.

Activities

(i) analyze single-cell / bulk RNA-sequencing data for revealing major gene programs. (ii) develop enhanced solutions for predicting master regulator transcription factors driving gene programs at the basis of CAR-T cell development.

Skills

The candidate must hold a Ph.D. degree in bioinformatics, computer science, or related. Essential qualifications include excellent programming skills in languages such as Python, Java, Perl, and/or R. Experience in next-generation sequencing and related functional genomic data analysis
(transcriptomics, ChIP-sequencing, etc) is a strong asset. Furthermore, experience in single-cell transcriptomics and/or gene regulatory network reconstruction is a plus for this application.
The successful applicant is expected to be an enthusiastic and self-motivated person. The applicant should have the skills to be an independent researcher.

Work Context

The team SysFate, driven by Marco Antonio MENDOZA (PhD / HDR; permanent CNRS researcher), is interested in understanding cell fate decisions from the reorganization of complex gene regulatory programs that are defining their biological state. SysFate is currently located within the French National Sequencing Center, Genoscope, in the city of Evry in the South of Paris – France.

Additional Information

EU-funded collaborative project T-Fitness (EIC Pathfinder 2022).

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