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Portail > Offres > Offre UMR8003-DANZYT0-002 - Chercheur Post-doctorant (H/F) sur l'étude électrophysiologique in vivo des mécanismes de la dégénérescence des motoneurones dans la Sclérose Latérale Amyotrophique

Post-doctoral researcher (M/F) to study mechanisms of spinal motor neurons degeneration in Amyotrophic Lateral Sclerosis (ALS) using in vivo electrophysiology

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mercredi 9 décembre 2020

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General information

Reference : UMR8003-DANZYT0-002
Workplace : PARIS 06
Date of publication : Tuesday, November 03, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 February 2021
Proportion of work : Full time
Remuneration : Between 2700 € and 3300 € brut monthly depending on the applicant experience
Desired level of education : PhD
Experience required : Indifferent

Missions

The postdoctoral researcher will contribute to a research program that aims at investigating the role of synaptic connectivity in the degeneration of spinal motor neurons in Amyotrophic Lateral Sclerosis (ALS). The postdoc will use ALS murine models and will combine chemognetics interventions using new viral vectors to modify synaptic properties with cutting edge in vivo electrophysiological methods to intracellularly record spinal motor neurons.
The initial work contract will last two years with a possible one year extension.

Activities

- Electrophysiological experiments aiming at intracellularly record spinal motor neurons in anaesthetized mice
- Surgery of small animal (mice)
- Intraspinal, systemic and intramuscular injections of viruses (level 1 containment)
- Data analysis and interpretation
- Bibliographical reviews
- Articles writing
- Communications at conferences and congresses

Skills

- Expertise in in vivo intracellular electrophysiology
- Expertise in microsurgery on small mammals
- Animal experiment training (conceptor level) and surgery training are mandatory (otherwise the applicant will receive the official trainings during the few first months)
- Team player
- Perseverance and endurance
- Hard worker
- Rigor
- Autonomy
- Good manual skills
- Good oral and written communication skills
- Fluency in english

Work Context

The Post-doc will work on projects financially support by ANR (the french agency for research), NIH-NINDS and Radala Foundation for ALS Research. The work will be supervised by Daniel Zytnicki in team "Motor Neurons and Neuromuscular Junctions" from the SPPIN unit at the Université de Paris. We are collaborating with a molecular biologist at the University of Ulm in Germany. The laboratory is located in the Saint-Germain des Prés district. The scientific environment is international including researchers in Neurophysiology, Molecular and Cellular Biology, Electrophysiology, Cell Imaging.

Constraints and risks

The in vivo electrophysiological experiments usually last 7 to 8 hours and they require good manual dexterity and to be very focused. Experiments are repeated 3-4 times every week.

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