Engineer in Biochemistry, Molecular and Cell Biology (M/F)

Job Description

Missions

The engineer will participate in a research project investigating an amino acid membrane transporter. His or her responsibilities will include applying electrophysiological techniques to cellular systems (Xenopus oocytes) or acellular systems (proteoliposomes) to measure transport activity and characterize the functional properties of the transporter. As part of the project, he or she may be required to conduct molecular and cellular biology experiments or biochemistry experiments.

Activity

- Design, execute, and interpret biology experiments
- Perform experiments using a new laboratory equipment
- Collect and process data for analysis
- Analyze, interpret, and validate results, and ensure their tracking and quality
- Maintain a laboratory notebook to record experiments
- Perform equipment maintenance
- Follow health and safety protocols
- Participate in team tasks and in the training of interns

Your Profil

Skills

Knowledge:
- Basic theoretical understanding of enzyme kinetics as applied to transporters
- Basic knowledge of membrane physiology
- Basic understanding of amino acid biochemistry and their metabolism
- Understanding of regulatory mechanisms
- Basic knowledge of molecular and cellular biology

Skills:
- Proficiency in common biochemistry techniques (assays, Western blot) and molecular biology techniques (site-directed mutagenesis, protein expression)
- Experimental organization and planning
- Practical proficiency in methods and software related to statistical analysis
- Written and oral scientific communication: drafting technical protocols and reports; oral presentation of results
- English language proficiency: C1
- Ability to apply Health and Safety regulations

Soft skills:
- Ability to work in a team
- Organizational skills
- Scientific rigor, attention to experimental details
- Independence and vigilance, sense of initiative

Your Work Environment

The research will be conducted within the Membrane Dynamics team at SPPIN, UMR 8003. The team's primary research focus is the identification and characterization of proteins located in the membrane of an intracellular organelle, the lysosome, which is involved in the turnover of cellular components and the regulation of metabolism and cell growth.

The laboratory is a joint research unit of the CNRS and Paris Cité University located in central Paris. It brings together approximately sixty people divided into eight teams. The research project is part of an ANR consortium with two teams from the Institute of Integrative Cell Biology (I2BC) in Gif-sur-Yvette.

The engineer will report to the team leader and work closely with the team's research engineer.

Join a dynamic team at the forefront of research on membrane transporters! The expertise in electrophysiology gained during this project will provide you with key knowledge to understand the dynamics of membrane transport, with potential applications in neuroscience and metabolism.

Constraints and risks

None

Compensation and benefits

Compensation

From 2570 € to 2800 € gross salary per month based on experience

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions