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Portail > Offres > Offre UMR7645-NICDAV-002 - Postdoc (H/F): Migrations cellulaires collectives dans l'embryon

Postdoc (M/F): Collective cell migrations in the embryo

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : lundi 10 octobre 2022

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General information

Reference : UMR7645-NICDAV-002
Workplace : PALAISEAU
Date of publication : Monday, September 19, 2022
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 January 2023
Proportion of work : Full time
Remuneration : Between 2800 and 4200 € gross according to experience
Desired level of education : PhD
Experience required : Indifferent

Missions

We are seeking a highly motivated candidate strongly interested in cell and developmental biology, to join our team and help us elucidate the mechanisms driving the collective cell migrations taking place in the early embryo.

Collective cell migrations are migrations in which the movement of a cell is influenced by its neighbours. Collective migrations are frequent and key to many physiological and pathological situations, yet, their cellular and molecular basis is just starting to be unraveled. A few years ago, we established that cells leading the embryonic axis extension undergo a collective migration. Our latest results demonstrate that cells perceive the mechanical forces exerted by their neighbours, and use it a directional information. Propagation of this information through the tissue allows large scale coordination of cell movements.


The project is funded through an ANR grant aimed at identifying the mechanisms linking mechano-perception at adherens junctions to actin dynamics and collective behaviours. Details of the project are open to discussion with the candidate.

Initial funding is for 1 year, and the candidate is expected to apply to fellowships to which he/she is eligible.

Activities

The project involves classical embryological approaches (embryo injections, cell transplants), live-imaging (regular confocal, two-photon, laser ablations, potentially light-sheet), image and data analysis, basic molecular biology. All techniques are in use in the lab, and all the required equipment is available.

Skills

The candidate should be enthusiastic and creative, have good communication skills and be eager to learn and work in a highly interdisciplinary lab. A background in developmental or cell biology is required. Skills in microscopy and/or basic coding are preferred but not required.

Work Context

This project will be carried out in the Laboratoire d'Optique et Biosciences at Ecole Polytechnique (Palaiseau, France), in the team of Nicolas David, who demonstrated the collective nature of the prechordal plate migration, and has a long standing experience in analysing in vivo cell migration. The laboratory is equipped with a fish facility and has all the required material and expertise for working on Zebrafish embryos. In addition, the LOB comprises world leading experts of fast and non-linear in vivo imaging. The project will directly benefit from their expertise and unique microscopes.
Ecole Polytechnique is located on the 'Plateau de Saclay', in the rapidly developing Paris-Saclay area, 25km from the center of Paris. The campus can easily be reached by public transport. It offers a wide range of activities (sports, culture, associations). More info on https://www.ip-paris.fr/en

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