Missions

Support and training mission in bioinformatics, cell culture, and functional genomic analyses, aimed at better understanding the interactions between transcription factors (TFs) and extracellular signaling pathways, particularly TGF-β and BMP.

Activités

Carry out cell cultures, including the differentiation of stem cells into spinal organoids
Develop user-friendly bioinformatics pipelines to analyze and compare protein recruitment profiles across the genome
Establish and optimize the ChIP-seq technique to analyze the recruitment of factors downstream of the TGF-β and BMP signaling pathways

Compétences

Solid experience in cell culture, particularly in the differentiation of stem cells into organoids
Practical knowledge of molecular and cellular biology techniques, especially ChIP-seq
Bioinformatics skills, including the development of pipelines for genomic data analysis (protein recruitment profiles, sequence analysis, etc.)
Ability to make bioinformatics tools accessible and usable by non-specialists
Good understanding of cellular signaling pathways, particularly TGF-β and BMP
Autonomy, rigor, and strong organizational skills in conducting experiments and analyzing results
Ability to work collaboratively in a multidisciplinary research environment
Strong communication skills for effectively presenting results both orally (meetings, seminars) and in writing (reports, publications)
Proficiency in scientific English (reading, writing, speaking)

Contexte de travail

The recruited candidate will work within the "Human Neurodevelopment and Disorders" team, led by Vanessa Ribes and Stéphane Nedelec, in collaboration with various members of the laboratory.

Contraintes et risques

Work in a Biosafety Level 2 (BSL-2) laboratory
Occasional on-call duties on weekends, depending on experimental needs
Extended screen time, particularly for bioinformatics data analysis