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Reference : UMR7592-ISALAD-018
Workplace : PARIS 13
Date of publication : Monday, December 02, 2019
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 February 2020
Proportion of work : Full time
Remuneration : between 2 600 and 3 600 € (gross salary per month), depending on experience
Desired level of education : PhD
Experience required : Indifferent
We are looking for a highly-motivated Post-doctoral Research Scientist with knowledge in the fields of gene expression and/or genetic stability to join the team “RNA biogenesis and genome homeostasis” at Institut Jacques Monod (CNRS/Université Paris Diderot, Paris, France – https://www.ijm.fr/en/975/equipes/rna-biogenesis-and-genome-homeostasis.htm)
Current work in the lab aims to uncover novel regulations targeting mRNA metabolism and to decipher their impact on gene expression patterns and genomic integrity. We are specially interested in understanding which cis- and trans-acting factors influence the formation of genotoxic DNA:RNA hybrids (R-loops), and thereby challenge genome dynamics and stability. The post-doctoral fellow will more particularly focus on the functional characterization of novel factors restricting hybrid-dependent genetic instability, which we previously uncovered through innovative screens in budding yeast.
The project will combine genome-wide approaches with mechanistic studies based on yeast genetics and molecular biology/biochemical assays.
The applicant will work under the supervision of the group leader, and is expected to :
- contribute to the design of the project,
- develop the methodologies,
- perform the experiments,
- analyze and communicate the data,
- manage the collaborations,
- write scientific reports (publications).
You will have a PhD in biological or biochemical sciences and demonstrable experience in genetics and molecular biology techniques. Previous experience in yeast biology or bioinformatic analyses of genomic data will be appreciated but is not essential. You will need strong organizational and team working abilities to take projects from conception to completion, as well as verbal and written communication skills in English (French is not mandatory). You will have a CV and publication record that would be competitive for national/international post-doctoral fellowships.
The Institut Jacques Monod (IJM) is one of the main centers for basic research in biology in the Paris area, and gathers around 30 research groups working on genome biology, cellular dynamics or development. The post-doctoral fellow will benefit from this highly dynamic scientific environment and from the leading-edge core facilities available within the IJM building, located on the University Paris-Diderot campus on the Paris left bank.
Constraints and risks
The position is funded by ANR (Agence Nationale de la Recherche), and is fixed term for 1 year with the eventuality of an extension. The position can start at any time after December 1st 2019. Applications including a CV and a cover letter summarizing current and future research interests, as well as the contact details of 2 referees, should be submitted through this website.
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