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Reference : UMR7592-ISALAD-015
Workplace : PARIS 13
Date of publication : Friday, November 08, 2019
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 January 2020
Proportion of work : Full time
Remuneration : between 2695,56 and 3600 € gross salary, depending on experience
Desired level of education : PhD
Experience required : Indifferent
During early mammalian development, the DNA methylation landscape is profoundly remodeled. The candidate will explore non-conventional ways that DNA methylation can impact gene regulation and genome regulation during this period. In order to carry this out, we will utilize a mouse embryonic stem cell differentiation model.
Cell culture : Mouse embryonic stem cell culture and differentiation, CRISPR-mediated genome and epigenome editing.
Molecular biology: DNA methylation and chromatin profiling. Chromosome conformation capture
Bioinformatics: Analysis of generated NGS data sets (not obligatory)
We are looking for independent researchers with strong communication skills, are open minded, and generous with their colleagues. A strong background in molecular biology techniques is required. Experience with mammalian cell culture would be helpful, but is not required. A computational background (or willingness to learn basic computational methods) is encouraged in the candidates.
The position is open in a recently formed team, which is generously supported by an ERC Starting Grant to carry out studies of Chromatin Dynamics in Mammalian Development.
The research is carried out within the Institut Jacques Monod, which is a joint CNRS - Université de Paris research unit with approximately 350 employees. The IJM is part of the INSB and is housed in a recently constructed University building on the Paris Left Bank campus located in the 13th arrondissement of Paris and accessible by all means of transport (Metro 14, RER C, T3 tramway, bus 62 and 89...)
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