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Portal > Offres > Offre UMR7590-SLAJON-002 - Chercheur postdoctoral (H/F): Conception et implémentation de méthodes hybrides combinant l'analyse d'images de cryo-microscopie électronique et la modélisation de la dynamique moléculaire

Postdoc (M/F): Hybrid methods combining cryo-EM image analysis and molecular dynamics modeling

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Français - Anglais

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General information

Reference : UMR7590-SLAJON-002
Workplace : PARIS 05
Date of publication : Monday, November 04, 2019
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 February 2020
Proportion of work : Full time
Remuneration : Between 2695 and 3841 € gross monthly salary (depending on experience)
Desired level of education : PhD
Experience required : Indifferent

Missions

The postdoctoral researcher will work on the development of algorithms and software to combine molecular dynamics modeling methods (normal mode analysis and molecular dynamics simulation) with cryo-electron microscopy image analysis methods, in the context of studying continuous conformational changes of biomolecular complexes. The new methods will be based on the methods developed in the team previously (https://doi.org/10.1016/j.str.2014.01.004 ; https://doi.org/10.1016/j.jsb.2014.09.005; https://doi.org/10.1016/j.sbi.2016.12.011).

Activities

Principal tasks:
- Conceive algorithms and implement them
- Conceive experiments with synthetic data to test new methods
- Use new methods to analyze experimental data provided by collaborators
- Write scientific articles
- Participate to scientific conferences and meetings with internal and external collaborators (physical and remote meetings)

Skills

- PhD degree in Computer Science, Applied Mathematics, Physics, etc.
- Strong programming skills
- Experience in development of image processing methods or in development of molecular dynamics modeling methods (e.g., normal mode analysis or molecular dynamics simulation)
- Good interpersonal skills
- Good oral and written communication skills
- Creativity
- Interest in structural biology data analysis

Work Context

This work will be performed in the context of a project funded by the ANR, at the Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC-UMR 7590, Sorbonne Université, 75005 Paris). The IMPMC is a joint research unit of the CNRS, the Sorbonne Université, and the Muséum National d'Histoire Naturelle, counting around 200 members. It is a highly pluridisciplinary laboratory, composed of researchers, researchers-teachers, and engineers with different backgrounds (physics, Earth science, biology, chemistry, computer science, etc.). Various experimental and theoretical research topics are studied at the IMPMC, such as elucidation of the structure of materials and macromolecular assemblies, investigation of their dynamic properties, study of interactions between the living world and the mineral world, etc.

Constraints and risks

18 months, with possibility of extension.

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