Reference : UMR7371-OLICOU-010
Nombre de Postes : 1
Workplace : PARIS 06
Date of publication : Wednesday, January 18, 2023
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 15 March 2023
Proportion of work : Full time
Remuneration : 2800 to 3300 euros monthly
Desired level of education : PhD
Experience required : Indifferent
The postdoctoral fellow will participate in an ERC Proof-of-Concept research project entitled StrokeMonitor. The objective of this project is to make it possible to diagnose delayed cerebral ischemia using three-dimensional ultrasound localization microscopy (ULM) in models and in the clinic.
- Couture, Olivier, et al. "Ultrasound localization microscopy and super-resolution: A state of the art." IEEE transactions on ultrasonics, ferroelectrics, and frequency control 65.8 (2018): 1304-1320.
- Chavignon, Arthur, et al. "3D transcranial ultrasound localization microscopy for discrimination between ischemic and hemorrhagic stroke in early phase." Scientific Reports 12.1 (2022): 1-11.
The postdoctoral fellow will be required to:
- Optimize 3D super-resolution ultrasound sequences
- Acquire super-resolution 3D ultrasounds on models
- Analyze ultrasound localization microscopy data
- Identify biomarkers in the context of disease models
- Participate in clinical ultrasounds
- Analyze data and apply identified biomarkers
The postdoctoral fellow has a solid foundation in medical imaging and data and image processing, as well as in acoustics.
The work will be carried out in the context of the Microvascular Physiology and Pathology team within the Biomedical Imaging Laboratory at Sorbonne University (CNRS, INSERM) and, punctually, at Physiopathology and Imaging of Neurological Disorders"(PhIND)GIP Cyceron, Caen, France
The ERC Proof-Of-Concept grant fits toward our overall goal of stroke diagnosis with 3D ultrasound localization microscopy (ULM). This technology came a long way from our first in-vitro experiments and our first presentation (Couture et al. IEEE IUS 2011). It has now spread to many great laboratories across the world, moved to 3D and is now being clinically tested in a number of settings.
As an application, our team at Laboratoire d'Imagerie Biomedicale (Sorbonne Université, Centre national de la recherche scientifique, INSERM) chose to target stroke because ultrasound imaging could be brought to each patient rapidly and easily, worldwide. The ERC POC StrokeMonitor will help us transfer transcranial 3D ULM in intensive care units for stroke monitoring. We will pursue this goal together with the team in Caen Maxime Gauberti, Denis Vivien, Cyrille Orset, Sara Martinez and others, along with people at Resolve Stroke: Vincent Hingot, Leo GURY, Arthur Chavignon , Aritz Zamacola.
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