Postdoc in immunometabolism and osteoimmunology (M/F)

Job Description

Missions

The recruited postdoctoral researcher will work on osteoclasts, multinucleated myeloid cells related to macrophages and primarily involved in bone resorption. Although their role in this process is well established, their immune functions and their position within the myeloid lineage remain poorly understood.
This work is part of the ANR-funded “DynamOC” program, which aims to decipher the phenotypic and functional heterogeneity of osteoclasts, particularly in relation to age and sex. The project is being carried out through a close collaboration between two teams at LP2M — the Osteoimmunology team, specialized in studying osteoclast diversity and immune functions, and the Myeloid Cells and Metabolism team, experts in immunometabolism — as well as several external partners.

The postdoctoral researcher's main missions will be:
- To study the metabolic properties of osteoclasts during development and aging using preclinical models with targeted alterations in specific metabolic pathways.
- To implement single-cell biology approaches and in vitro functional assays to characterize the effects of metabolic modifications on osteoclast differentiation and functions, particularly their immune function.
- To actively collaborate with all partners of the ANR DynamOC program.

The position is offered for an initial period of one year, with the possibility of extension up to three years depending on project progress.

Activity

- Cell culture: primary culture of osteoclasts and monocytic cells, as well as other immune cells.
- Imaging, flow cytometry (including spectral), and cell sorting.
- Animal models.
- Metabolic analyses and in vitro immune assays.
- transcriptomic analysis
- Writing of research projects and scientific articles.
- Supervision of students.

Your Profil

Skills

Knowledge and expertise:
- Excellent expertise in monocyte immunology and/or osteoclast biology.
- Strong skills in animal experimentation; authorization to perform animal research is desirable.
- spectral flow cytometry
- transcriptomic analysis
- Proficiency in scientific English

Skills:
- Ability to design and carry out scientific studies, including experimental conception and implementation.
- Capacity to organize daily work independently.
- Commitment to staying up to date with scientific literature.
- Ability to present research findings in meetings and conferences.
- Strong writing skills for project proposals, reports, and scientific articles; strong synthesis and analytical abilities.

Personal qualities:
- Ability to work both independently and as part of a team; excellent teamwork spirit.
- Scientific creativity and curiosity.
- Good organizational skills.
- Capacity to take on responsibilities as a project leader.
- Leadership and mentoring skills (supervision of students).

Your Work Environment

The Laboratory of Molecular PhysioMedicine (LP2M) in Nice, France, is a joint research unit of the CNRS, France's leading national research organization, and Université Côte d'Azur, recognized as an “Université d'Excellence.”
LP2M is a rapidly growing laboratory specializing in immunophysiology. It offers a stimulating, dynamic, and high-quality research environment, particularly in immunology, with access to all necessary state-of-the-art technological platforms.
The laboratory benefits from strong clinical integration and international connections with leading research teams in the field. It therefore provides an ideal setting for an ambitious early-career researcher wishing to develop a long-term scientific project in a dynamic, collaborative, multidisciplinary, and international environment.

Located within the Faculty of Medicine in Nice, LP2M enjoys a privileged setting in the heart of the French Riviera , between the sea and the mountains, offering a work environment that is intellectually stimulating and personally enriching.

Compensation and benefits

Compensation

between €3,072 and €4,258.87 gross per month, depending on experience.

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions