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Reference : UMR7360-CATPIE-007
Workplace : VANDOEUVRE LES NANCY
Date of publication : Monday, September 13, 2021
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 17 January 2022
Proportion of work : Full time
Remuneration : between 2690€ and 3099€ gross monthly
Desired level of education : PhD
Experience required : 1 to 4 years
Determine the mechanisms of microalgae responses to nanoparticle stress, using in-situ measurements at nano- and micro-scales. More specifically, atomic force microscopy (AFM, in imaging and force spectroscopy mode) and confocal micro-spectroscopy will be used to monitor the dynamics of bio-physicochemical taking place on the surface and in the intracellular medium of living microalgae.
The proposed methodology will track the distribution of NPs: adherence to biosurface, internalization, and compartmentalization in the cell. To better understand the mode of action of NPs, links will be established between the algal changes induced by NPs at the molecular level, the deleterious effect of cell-scale NPs and indicators of the physiological status of cells at the algal population level. Depending on the development of the project, the candidate may be involved in other aspects of the study, such as the application of unmarked microscopy to microalgae.
The person will be responsible for conducting experiments, analyzing data, writing scientific reports and publications, sharing and discussing results
-Very good AFM and biophysical skills
- Photonics skills and knowledge
- Good knowledge in physico-chemistry, colloid science;
- Strong motivation to work on an interdisciplinary project, and ability to interact with different scientific communities;
- Microbiology skills would be a plus but not mandatory
- English level B2
The LIEC is a joint research unit (UMR 7360) created in January 2013 whose primary objective is to understand the functioning of continental ecosystems that are severely disturbed by human activity, with the aim of their rehabilitation. To this end, we carry out interdisciplinary research combining the concepts and methods of environmental mineralogy, soil science, microbial ecology, colloidal physico-chemistry, ecotoxicology and functional ecology.
The proposed project is funded by a JCJC ANR (ANATOMIC).
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