Missions

Selective deuteration of molecules catalyzed by nanoparticles.

Activités

1) Catalyst synthesis and optimization :
Prepare supported nanoparticles and functionalize them with commercial phosphines.
Characterize the materials using TEM, XPS, XRD, ICP-MS/OES and validate their structural integrity.
2) Catalytic deuteration tests :
Evaluate catalyst activity for hydrogenation/deuteration of model molecules in batch reactors.
Optimize reaction conditions (pressure, temperature, phosphine/Ni ratio).
Analyze products and map deuteration sites.
3) Benchmarking and collaborations:
Compare the performance of the PRELUDE catalyst with commercial catalysts (e.g., Ru/C).
Collaborate with academic and industrial partners.
4) Dissemination and valorization:
Write robust experimental protocols.
Present results at targeted conferences and publish in peer-reviewed journals.

Compétences

PhD in organometallic chemistry, catalysis, or materials chemistry.
Strong command of analytical techniques: NMR, TEM, XPS, XRD.
Experience in catalytic reactivity: handling pressurized reactors, optimization of reaction parameters.
Autonomy, rigor, and initiative.
Proficiency in scientific English (writing and presentations).

Contexte de travail

The PRELUDE project aims to develop an innovative nickel phosphide (Ni₂P)-based nanocatalyst modified with phosphines for selective and late-stage deuteration of organic molecules. This catalyst, compatible with industrial continuous-flow processes, will reduce costs (replacement of ruthenium/iridium by nickel) and improve regioselectivity. The deuterated compounds market is rapidly growing (projected to reach €1 billion by 2033), particularly in the pharmaceutical, OLED, and metabolic tracer sectors.
You will join an interdisciplinary team at CINaM, under the supervision of Sophie Carenco (CNRS Research Director), an expert in nanocatalysis and surface chemistry.

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.

Contraintes et risques

Handling of nanoparticles, chemicals, and gases. The recruited person will receive appropriate health and safety training.