Missions

- Plan the project and experiments, carry out the experiments and compile the results - - Present the results internally -
- Maintain up-to-date knowledge of approaches and techniques for developing therapeutic oligonucleotides

Activities

- Synthesis of antisense oligonucleotides and characterisation of reaction products by HPLC-UV and UPLC-MS/MS -
Drafting of reports presenting intermediate and final results.
- Participation in laboratory activities: joint tasks, in-house training in the techniques developed.

Skills

Knowledge : - Development of therapeutic oligonucleotides Skills: - Design and implementation of protocols for the synthesis of therapeutic antisense oligonucleotides. - Experience in chemistry and analytical chemistry (HPLC, UPLC, MS).
Skills: - Ability to communicate orally and in writing in French and English. - Ability to work independently under the direction of the project leader.

Work Context

Full-time position at RNAnoTher (INSERM U1326, CiNAM-CNRS UMR7325) headed by Dr Palma Rocchi, focusing on the development of mRNA-based drugs in the context of castration-resistant prostate cancer (CRPC).
Facilities: office at RNAnoTher, computer, access to bibliographic and computational resources.

The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.

Constraints and risks

No particular risks or constraints.