Missions

Gut bacteria must constantly adapt to simultaneous and variable stresses. While many bacterial signal transduction systems have been characterized individually, the mechanisms by which bacteria integrate multiple concurrent signals remain poorly understood. Antimicrobial peptides (AMPs) are ubiquitous in all life forms, produced both by host immune systems as a first line of defense and by commensal bacteria during microbial competition. Despite their importance, predicting bacterial response to AMPs remains challenging. This project aims to elucidate how commensal bacteria in the gut sense and integrate multiple environmental signals, with a focus on AMPs. To address this question, the postdoc will combine multidisciplinary research techniques (-omics, Tn-seq, molecular biology and biochemistry).

Activités

To address this question, the postdoc will combine multidisciplinary research techniques (-omics, Tn-seq, molecular biology and biochemistry).

Compétences

The candidate should hold a PhD in microbiology, biochemistry, molecular biology, or a related field, with a strong background in bacterial physiology and molecular mechanisms. Excellent oral and written communication skills in English are required, as well as the ability to work both independently and collaboratively within a team. Knowledge or experience in bioinformatics, proteomics, and/or metabolomics will be highly appreciated. The candidate should demonstrate strong motivation and enthusiasm for the research topic, along with a proactive and creative problem-solving approach.

Contexte de travail

iSm2 is a cutting‑edge research institute located in Marseille and hosted within IM2B at Aix‑Marseille University. The project is carried out within the Biosciences team, an interdisciplinary group bringing together expertise in chemistry, biology, and biophysics. This project will be led by an early‑career group leader who fosters a collaborative, interdisciplinary environment and an encouraging innovative approach, while the "Biosciences" team provides the collaborative expertise and resources needed for success.

Contraintes et risques

iSm2 is a cutting‑edge research institute located in Marseille and hosted within IM2B at Aix‑Marseille University. The project is carried out within the Biosciences team, an interdisciplinary group bringing together expertise in chemistry, biology, and biophysics. This project will be led by an early‑career group leader who fosters a collaborative, interdisciplinary environment and an encouraging innovative approach, while the "Biosciences" team provides the collaborative expertise and resources needed for success.