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Reference : UMR7288-JACRIC-003
Workplace : MARSEILLE 09
Date of publication : Monday, December 03, 2018
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 February 2019
Proportion of work : Full time
Remuneration : 2605€ à 3700€ gross monthly salary according to experience
Desired level of education : PhD
Experience required : Indifferent
The objective of this project is to determine the role of a transient potassium current (IA) in the integration mechanisms of nociceptive and non-nociceptive messages by spinal cord dorsal horn (SCDH) interneurons. Generally speaking, depending on its activity, which is strongly regulated by a large number of mediators, IA is able to reduce or increase the discharge of the action potentials emitted by neurons. In the SCDH, we showed in 2018 that it varies strongly depending of the interneurons types and our preliminary data suggest that it can be highly modulated in some pain models. The project aims to continue this investigation.
The project will be carried out using the patch-clamp technique to establish in which SCDH region and in which types of SCDH interneurons IA is modulated. The origin of these modulations will be investigated using different types of mouse models (wild mice, or those in which inhibitory interneurons are identifiable or have a deletion for TAFA4 whose analgesic function has been established in our team) subjected or not to a neuropathic pain model. All these investigations will be complemented by a pharmacological approach.
- The post-doctoral researcher should have training in biophysics, particularly in the field of voltage-dependent ionic currents, and master the technique of patch-clamp recording on spinal cord slices in adult mice. He must also have a solid knowledge of pharmacology applicable to the study of intrinsic and synaptic plasticity.
- Good practice of English
The Institut de Biologie du Développement de Marseille (IBDM - UMR7288) located on the Luminy Campus, under the joint supervision of CNRS and AMU, brings together about 240 people working in 21 research teams and 11 technical platforms and services, and explores the field of developmental biology and associated pathologies.
The activity will be carried out in the "Chronique pain : molecular and cellular mechanisms" team headed by Mr Aziz MOQRICH. The team being composed of several nationalities, the practice of the English language is essential.
Constraints and risks
Please post a CV, a cover letter and ideally a letter of recommendation
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