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Portail > Offres > Offre UMR7285-JERDES-003 - Post-doctorant (H/F) en synthèse de composés d'intérêt biologique

Post-doctoral researcher (M/F) in synthesis of compounds of biological interest

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 16 février 2023

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General information

Reference : UMR7285-JERDES-003
Nombre de Postes : 1
Workplace : POITIERS
Date of publication : Thursday, January 12, 2023
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 March 2023
Proportion of work : Full time
Remuneration : From 2805 to 3963 € salary according to previous positions
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

At the CNRS, within the IC2MP, the postdoctoral fellow will be a member of the "OrgaSynth" team and his/her work will be part of the glycochemistry team projects. He/she will work under the supervision of the glycochemistry group staff (researcher in glycochemistry) and will be in charge of synthesizing and characterizing C-glycosides and their analogues obtained by means of a dual catalysis. The produced molecules will then be assayed by foreign collaborators.

Activities

The post-doctoral fellow will carry out the stereodivergent synthesis of innovative C-glycosides bearing two contiguous stereogenic centers using a dual catalysis exploiting N-metallo-ketene imine complexes. The reactivity of these complexes towards the target organic substrates will be explored and optimized. Prior to biological testing with collaborators, the obtained molecules will have to be fully characterized (NMR, IR, HRMS, etc..). The postdoctoral fellow will be in charge of writing scientific reports on the progress of the work and publications on the major results obtained, and will have to present the results regularly in synthetic oral presentations. He/she will also have to participate in the scientific life of the research team.

Skills

The candidate must have an expertise and a strong interest in multi-step synthesis and must hold a PhD in organic chemistry. He/she must have strong skills in synthesis under inert atmosphere using organometallic species and structural analysis of organic molecules (MS, NMR). Experience in glycochemistry would be a plus but is not mandatory. The activity requires a good level of English to work in a multicultural team and to disseminate scientific results: writing scientific reports, articles, presentations in English. The candidate must be able to work in a team and independently.

Work Context

The Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP UMR 7285) is a multidisciplinary joint research unit (UMR) of the University of Poitiers and the CNRS (INC and INSU) in the fields of chemistry and geosciences. Created in 2012, it results from the merger of four UMR (LACCO, LCME, SRSN and HYDRASA) historically present in Poitiers for over 40 years. It brings together about 260 people (about 100 researchers and teacher-researchers about 50 permanent technical staff, and about 110 non-permanent staff including 90 PhD students). Since its creation, the IC2MP has developed a scientific policy around sustainable chemistry by integrating more particularly (1) the synthesis of molecules and materials according to atomic and energy saving processes and (2) their interactions with natural environments (reactivity, transfer, bioaccumulation, persistence, etc.).
The postdoctoral fellow will be a member of the "OrgaSynth" team, which is composed of 15 permanent staff (researchers, teacher-researchers and ITA/BIATSS) and about 20 non-permanent staff (PhD students, postdoctoral fellows, masters). The OrgaSynth team is specialized in the study of the reactivity of organic compounds and the multi-step synthesis of high added value molecules for biological/therapeutic purposes.
The scientific project that will be entrusted to the recruited person is part of an ANR project in collaboration with other teams based in Orléans (bimetallic catalysis), Rouen (asymmetric catalysis) and Paris (total synthesis); frequent interactions with these collaborators (videoconferences), and even travels, are therefore to be expected.

Constraints and risks

Missions in France

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