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Reference : UMR7284-MIGGOD-001
Workplace : NICE
Date of publication : Friday, July 19, 2019
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 November 2019
Proportion of work : Full time
Remuneration : From 2643.22 € gross monthly to 3729.53 € gross monthly depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years
Telomeres, the ends of chromosomes, shorten at each round of cell division. Unlike the commonly used mouse, zebrafish have similar telomeres to humans and show telomere shortening with age (Carneiro et al. DMM 2016). We recently shown that fish defective for telomerase undergo premature aging (Carneiro et al. PLoS Genetics 2016).
Interestingly, telomeres shorten at different rates in different organs. The gut is one of the first organ to exhibit very short telomeres and, consequently, cellular and morphological defects that affect gut function. The importance of gut function and gut flora for organism health and lifespan is well established. Thus, is it possible to extend lifespan by simply delaying aging in the gut?
We propose to make use of our zebrafish premature aging model to study whether organs communicate their aging status. By reactivating telomerase specifically in the gut of these fish, we expect not only to counteract the defects of gut, but if our idea is correct, we will delay aging of the whole organism and, hence, increase its lifespan. In addition, we will attempt to revert the defects of premature aging by manipulating the gut flora and preserve gut function during aging.
We are looking for a highly motivated postdoc willing to integrate knowledge spanning from molecular to organism biology and disease. Previous experience on zebrafish is not mandatory, but will be favourably regarded.
Our laboratory was responsible for the description of the zebrafish telomerase mutant and we have been studying the consequences of short telomeres with an organism perspective, integrating cellular biology to tissue function in health and disease (Henriques & Ferreira, Curr Opin in Cell Biol 2013).
We recently relocated to beautiful city of Nice in the south of France to the Institute for Research on Cancer and Aging of Nice (IRCAN). Several core facilities at the cutting edge of technology and services available at the IRCAN institute provide all the equipment and infrastructures required. The zebrafish facility (100m²) supports zebrafish housing, imaging equipment and embryo manipulation workstations. The histopathology facility (25m²) provides a service for sample processing, embedding, sectioning and tissue section staining. Its light microscope will also allow for the analysis of stained tissue sections for this project.
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