Missions

The post-doc will contribute to the study of Saccharomyces genomes with focus on studying telomeric regions using “long-read” sequencing. This includes analysis of natural, engineered strains and replicative aged cells. The post-doc will study the impact telomere length phenotype and its role in regulating the species fitness landscape. The postdoc will also collaborate on other projects currently ongoing in the group (https://ircan.org/en/research/gianni-liti).

Activités

The postdoc will perform both experiments and computational analysis to characterise telomere length variation:

Main tasks:
- Yeast genome editing
- Yeast phenotyping
- Yeast genome sequencing with long-read technology
- Data analysis

Compétences

Previous experience in molecular biology and genomics is essential.
Advanced knowledge of telomere biology, ageing biology and genome analysis by next generation sequencing is essential as well as a strong statistical background.

Contexte de travail

The postdoctoral fellow will be assigned to Dr Gianni LITI's team "Population genomics and complex traits". The team is one of the founding teams of IRCAN and is located at the Faculty of Medicine of Nice. The team has all the necessary equipment for yeast genetics and genomics experiments and has access to state-of-the-art microscopy, cytometry and genomics facilities as well as computing and storage servers.

Contraintes et risques

The system we are working with (yeast) is known to be safe and non-pathogenic. Some of the chemicals used in the experiments are toxic and must be handled in accordance with the instructions. A safety induction will be given before the start of the experimental activities.