Missions

The recruitment is part of the INSERM PCSI research contract CytoCu4Glioma, which focuses on the study of cytotoxic copper complexes for therapeutic purposes in glioblastoma.
The successful candidate will develop spectroscopic approaches (electron paramagnetic resonance, UV-visible, ...) to characterize Cu complexes, study their stability, redox behavior, and their fate within cells.
Keywords: Copper, Metallic Stress, Bioinorganic Chemistry, EPR

Activités

- Spectroscopic characterization of Cu complexes as therapeutic agents
- Stability studies, reactive oxygen species production, spin trapping
- In cell EPR
- Data analyses
- Report writing, oral presentations, article writing.

Compétences

Knowledge: knowledge of copper complexes, biophysical methods. Knowledge of biology. Proficiency in scientific English. Skills: experimental work on inorganic complexes and biological samples; recording spectra (UV-visible, fluorescence, EPR, etc.); data analysis. Interpersonal skills: ability to work/communicate in a multidisciplinary environment (physics, chemistry, biology), teamwork.

Contexte de travail

Integration into the team Biophysics of Metalloproteins and Dynamic Systems (https://bip.cnrs.fr/groups/bip07/, PI: Pierre Dorlet) within the Laboratory of Bioenergetics and Protein Engineering in Marseille on the CNRS Joseph Aiguier campus. Full time position in accordance with the internal regulations of the unit and the laboratories involved in the collaboration. Computer workstation equipped with the necessary software. Wet bench and laboratory equipment for samples preparation. UV-visible spectrometers, CD, etc. EPR platform specialized in life sciences.

Contraintes et risques

Usual constraints associated with working in a biology laboratory. Possible travels for collaboration and attending conferences.