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Reference : UMR7280-HUGLEL-001
Workplace : MARSEILLE 09
Date of publication : Monday, February 15, 2021
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 May 2021
Proportion of work : Full time
Remuneration : between 2728.26 and 3881.29 euros gross monthly salary depending on experience
Desired level of education : PhD
Experience required : Indifferent
In the frame of the ANR project Phagomic, the researcher will study the role of the different Peyer's patch phagocyte populations in intestinal immunity. She/he will
in particular study the immune response occurring at the time of weaning and leading to the education and maturation of intestinal immunity. Using different models of Peyer's patch phagocyte depletion, she/he will study the relationships between the profound microbiota modification due to the change in diet induced by weaning, the immune functions of the phagocytes and the development of adaptive intestinal immunity.
The researcher will use a wide variety of techniques including animal experimentation, confocal microscopy, flow cytometry and cell sorting, cell culture and scRNA-seq analyses to dissect the events leading to the initiation of the immune response in Peyer's patches at the time of weaning.
Candidates must have a PhD validated by one or more high rank publications as first author. Training in animal experimentation is required as well as a good knowledge of flow cytometry and mucosal immunity. Although not mandatory, notions of scRNAseq and bioinformatics will be an asset.
The Marseille-Luminy Immunology Center (CIML) is a joint research unit of the CNRS, INSERM and Aix-Marseille University internationally recognized in its discipline. The CIML is composed of about 200 people of all nationalities working in 16 research teams exploring the different fields of immunity. Located in the Luminy Science and Technology Park in Marseille (France), it has state-of-the-art technological platforms (flow cytometry, microscopy, genomics). The person recruited will join the research team "Immunology and biology of host/pathogen interactions" led by Jean-Pierre GORVEL within the CIML and will work under the responsibility of Hugues LELOUARD in the research group dedicated to the study of the intestinal immune response and the role of Peyer's patch phagocytes. This group is currently composed of 3 PhD students, 2 researchers and a technician.
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