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Portal > Offres > Offre UMR7277-STENOS0-002 - Post-Doc H/F: Rôle de Myosin1D et du cytosquelette d'actine dans l'asymétrie Droite-Gauche

Role of Myosin1D and the actin cytoskeleton in Left-Right Asymmetry

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UMR7277-STENOS0-002
Workplace : NICE
Date of publication : Thursday, November 21, 2019
Type of Contract : FTC Scientist
Contract Period : 36 months
Expected date of employment : 1 January 2020
Proportion of work : Full time
Remuneration : Between 2617 € and 3729 € (monthly gross pay), depending on experience.
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

Role of Myosin1d and the actin cytoskeleton in Left-Right Asymmetry: molecular and cellular approaches

Activities

A 3-year Post-Doc position is available in the group of Dr Stéphane NOSELLI at the 'institut de Biologie Valrose' (iBV), Université Côte d'Azur in Nice, FR (http://ibv.unice.fr/research-team/noselli/)

Our lab investigates the origin of biological chirality and the role of the actin cytoskeleton and Myosin1D in this fundamental property. We approach this problem by studying how Left-Right asymmetry is established in Drosophila, using multidisciplinary approaches addressing a number of primary questions: How is symmetry breaking taking place? What are the molecular determinants of asymmetry/chirality? How molecular chirality propagates to higher order organ asymmetry, bridging different biological scales?
Our lab has pioneered the study of LR asymmetry using Drosophila as a model system, through identification of key molecular processes and players (Myo1D, PCP signalling, Hox, Adherens junction). This project aims at characterizing the role of the actin cytoskeleton in LR symmetry breaking at both molecular and cellular level. Focus will be made on candidate genes recently identified through genetic screening. The project will involve collaborative work with the groups of Dr. Laurent Blanchoin and Manuel Théry (www.cytomorpholab.com).

Highly motivated candidates with original thinking and background in Developmental Biology, Cell Biology, Biochemistry are encouraged to apply. Interested candidates can contact Stéphane Noselli (noselli@unice.fr).

The 'institut de Biologie Valrose' (27 teams; 300 persons; 25 nationalities) is an international institute (English is the working language) with a rich and vivid scientific environment. iBV provides state of the art core facilities, with a collaborative and lively atmosphere in a gorgeous city/region. (ibv.unice.fr)

Selected publications:

Speder et al., Nature 2006
Gettings et al., PLoS Biology 2010
Suzanne et al., Cur Biol 2010
Petzoldt et al., Development 2012
Coutelis et al., Dev Cell 2013
Géminard et al., Genesis 2014
Coutelis et al., EMBO Reports 2014 Gonzales-Morales et al., Dev Cell 2015
VandeBor et al., Cell Reports 2015
Rousset et al., PLoS Genetics 2017
Roumengous et al., Cell Reports 2017
Juan et al., Nat. Com. 2018
Tingler et al., Cur. Biol. 2018
Lebreton et al., Science 2018

Skills

Developmental Biology
Cellular biology
Biochemistry
Genetics
Previous experience with the Drosophila model is a plus but is not necessary

Work Context

The 'institut de Biologie Valrose' (27 teams; 300 persons; 25 nationalities) is an international institute (English is the working language) with a rich and vivid scientific environment. iBV provides state of the art core facilities, with a collaborative and lively atmosphere in a gorgeous city/region. (ibv.unice.fr)

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