Reference : UMR7277-GUISAN-005
Workplace : NICE
Date of publication : Thursday, June 23, 2022
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 September 2022
Proportion of work : Full time
Remuneration : 2739 à 3148
Desired level of education : PhD
Experience required : Indifferent
Ion channels generate the electrical signals with which the nervous system senses the world, processes information, creates memories and controls behavior. The Two-Pore-Domain Potassium channels (K2P), by regulating neuronal excitability, are involved in several physiological and pathophysiological paradigms such as mood regulation, pain and migraine induction. Therefore, they constitute attractive pharmacological targets providing motivation for developing a deeper understanding of their functions. The absence of specific pharmacology, as well as some biochemical intrinsic properties have made their study difficult. To overcome these problems, we have developed a novel scheme for optical remote control of native channels.
Using these tools, combined with single molecule fluorescence and behavioral assays, the project aims to address K2P channel's physiological and pathological function (migraine and pain induction) along with finding new drug targets.
The ideal candidates will have a solid background in electrophysiology and molecular biology and/or cell imaging and/or optogenetic.
The Institute of Biology Valrose (http://ibv.unice.fr/EN/index.php) is a multidisciplinary institute, benefiting of an international scientific environment with over 200 researchers working in 27 different groups and localized in the city of Nice on the French Riviera
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