Missions

Applications are invited for a postdoctoral research fellow to work on an exciting research program at the cross-road of human genetics, developmental and stem cell biology. Aim of the present project is to delineate the molecular function of GREB1L, a gene involved in congenital abnormalities in human patients. You will use a combination of in vitro differentiation experiments (3D organoids), genetic studies in mice, and biochemical approaches to identify molecular pathways driving mesoderm differentiation and patterning. You will perform in vitro, ex vivo and in vivo experiments and analyse model systems on the phenotypic, molecular and genomic level. You will be working in an international research environment and benefit from state of the art equipment. The contract is for a period of 30 months

Activités

Activities
• Planning and execution of experimental studies
• Biochemical analysis of protein-protein interactions
• CRISPR/Cas9 mediated mutagenesis of mouse ES and/or human IPSCs
• in vitro differentiation of murine and human stem cells into mesoderm and gastruloids
• Genetic analysis in mouse models including histological (3D imaging) and molecular phenotyping
• “Omics” data analysis
• Documentation and interpretation of results; presentation at scientific conferences
• Writing manuscripts for publications

Compétences

We expect candidates to be highly motivated, have a PhD degree in biological or biomedical sciences and have worked in the field of developmental biology/mouse genetics. Excellent English communication and interpersonal skills are essential. A background in analysing omics data and knowledge in the field of cellular metabolism are an advantage.

Contexte de travail

The Institute of Biologie Valrose (iBV) is a centre of excellence funded by the CNRS, Inserm and the University Cote d'Azur (Nice). The iBVs remit is to unravel the basic principles governing organism development and identify the molecular basis of diseases including cancer. You will have access to state-of-the-art technology platforms including cutting-edge microscopy infrastructure, cytometry, histology and bioinformatics platforms and animal facilities of various model organisms.
The Schedl team is interested in signalling pathways that ensure proper organ development and tissue maintenance and their links with cancer. Further information on the research topics of the Schedl team can be found at http://ibv.unice.fr/EN/equipe/schedl.php

Contraintes et risques

Risks associated with laboratory work (biological agents, chemicals).