Characterization of Autoantibodies in Patients with PLA2R1-Associated membranous Nephropathy (M/F)
New
- Researcher in FTC
- 12 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Pharmacologie Moléculaire et Cellulaire
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
06560 VALBONNE
Contract Duration
12 months
Date of Hire
01/10/2026
Remuneration
in between 2991 and 4756 euros full salary depending on experience
Apply Application Deadline : 25 September 2026 23:59
Job Description
Missions
The researcher will independently conduct the characterization of autoantibodies in patients with PLA2R1-associated membranous nephropathy, from molecular characterization through in vitro and in vivo studies.
Activity
Produce various antigens (PLA2R1 and its fragments) in recombinant form.
Produce monoclonal antibodies from patients in the form of mAb, Fab, and scFv.
Characterize the molecular and functional properties of the interactions between PLA2R1 and patient antibodies, both in vitro and in vivo.
Develop inhibitors of these interactions and validate them in various assays.
Present results, interpret data, validate findings, and take initiative independently.
Your Profil
Skills
Extensive experience in molecular and cellular biology, protein engineering, and recombinant production in prokaryotic and eukaryotic systems, ideally involving antibodies and secreted proteins with disulfide bonds
Ability to work independently and as part of a team
Strong organizational skills
Attention to detail and rigor
Skills:
In-depth mastery of techniques in structural and molecular biology, biochemistry, cell biology, and immunology is essential.
Proficiency in using computer tools and software dedicated to data processing and the presentation of results.
Your Work Environment
Recruitment for this position is open as part of a program funded by the ANR and other sources. The researcher will work in the team Molecular Pathophysiology of Phospholipase A2 and Its Mediators, under the direct supervision of the team leader. The team is studying PLA2s and their receptor PLA2R1, which are therapeutic targets for various inflammatory and autoimmune diseases.
The IPMC is a multidisciplinary institute with approximately 200–250 staff members, comprising 20 research teams.
The employee will be trained on the potential risks associated with the project by the team leader upon arrival at the laboratory. The employee will also receive the employee training provided by the biological and chemical risk prevention assistants.
Constraints and risks
Risks associated with biological agents, chemicals, and the use of screens.
Compensation and benefits
Compensation
in between 2991 and 4756 euros full salary depending on experience
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7275-GERLAM-005 |
|---|---|
| CN Section(s) / Research Area | Pharmacology, bio-engineering, imaging, biotechnology |
| Relevant experience | 1 to 4 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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