Missions

The Marseille Cancer Research Center (CRCM) is recruiting a Research Engineer on a fixed-term contract to join the DOSynth Chemistry Platform, under the supervision of Dr. Sébastien Combes, to develop an ANR-funded project in the field of nutrition.

In collaboration with the group of Emmanuelle Reboul at the Cardiovascular and Nutrition Research Center (C2VN), the recruited candidate will design, synthesize, and characterize functionalized vitamins to help identify transport proteins in the context of nutritional deficiencies.

Activities

Design and carry out the synthesis of vectorized fat-soluble vitamins
Monitor reaction progress and characterize the products formed
Select appropriate synthesis techniques and protocols; develop procedures and operating methods to generate a small series of derivatives
Conduct structure–activity relationship (SAR) studies to maintain affinity and selectivity for transport proteins
Write procedures and reports on synthetic results
Maintain scientific and technical watch
Manage basic supply needs and equipment

Skills

Core Skills
Knowledge:
In-depth knowledge of chemical synthesis methods
Strong background in medicinal chemistry
General knowledge of vitamin modification techniques
General knowledge of organic synthesis, separation, and purification methods
General knowledge of chemical analysis and characterization techniques
Basic knowledge of safety risks and regulations related to hygiene and lab safety
Basic understanding of handling, storage, and disposal of chemicals
Good level of scientific English (reading, writing, speaking)
Technical Skills:
Conduct organic syntheses
Perform physicochemical characterization of synthesized compounds
Use software tools for data analysis, reporting, and result presentation
Report and communicate findings
Work collaboratively and share expertise
Organize and prioritize tasks
Maintain a lab notebook and write synthesis protocols
Soft Skills:
Good listening skills
Organizational skills and autonomy
Team spirit and interpersonal skills
Rigor, reliability, and critical thinking
Initiative and proactivity

Work Context

The CRCM is a joint research unit (UMR) affiliated with INSERM, CNRS, Institut Paoli-Calmettes, and Aix-Marseille University. The center's chemistry platform develops applied research programs in the health sector. The laboratory is located on the Timone Health Campus, at the Faculty of Pharmacy of Aix-Marseille University.

Constraints and risks

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