General information
Offer title : M/F Wide-field multiphoton and coherent Raman microscopy using speckle illumination for biomedical applications: Theoretical investigation (H/F)
Reference : UMR7249-HERRIG-025
Number of position : 1
Workplace : MARSEILLE 13
Date of publication : 28 November 2025
Type of Contract : Researcher in FTC
Contract Period : 12 months
Expected date of employment : 2 February 2026
Proportion of work : Full Time
Remuneration : Between 3 132€ and 4 342€ gross monthly
Desired level of education : Doctorate
Experience required : 1 to 4 years
Section(s) CN : 08 - Micro and nanotechnologies, micro and nanosystems, photonics, electronics, electromagnetism, electrical energy
Missions
Histology is routinely performed in hospitals and involves taking a small tissue sample (biopsy), which is then sliced, stained, and examined by a specialist to diagnose its cancerous nature. This process is time-consuming (1–24 hours) and prevents optimal patient management during surgical procedures or endoscopic exploration. This postdoctoral research project aims to develop a completely novel optical technology for instantaneous three-dimensional histological imaging of biopsies, without the need for labeling or prior preparation.
The proposed approach uses wide-field coherent Raman imaging with random speckle field illumination to reconstruct a 3D z-stack image of the chemical bonds present in the sample, without any labeling or preparation. This method closely integrates the latest technological innovations in lasers, microscopy, and low-noise optical detection with advanced digital reconstruction techniques.
This postdoctoral research program will focus on theoretical aspects. The work will involve modeling speckle illuminations and nonlinear optical contrasts (two-photon fluorescence, SHG, CARS). The resilience of speckle illumination approaches in scattering media will also be investigated. Theoretical predictions will be compared with experimental results obtained by other team members.
Activities
The activity will involve carrying out the research program. This will include mathematically formalizing the illuminations and optical contrasts (both linear and nonlinear) and conducting numerical simulations. The results will be formatted for presentation.
Skills
Applied mathematics
Electromagnetism
Numerical simulations
Data presentation
Work Context
The project is being conducted as part of the ERC SpeckleCARS project:
https://www.fresnel.fr/wp/projet-europeen/erc-specklecars/
The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.
Constraints and risks
None