Informations générales
Intitulé de l'offre : M/F Wide-field multiphoton and coherent Raman microscopy using speckle illumination for biomedical applications: Theoretical investigation (H/F)
Référence : UMR7249-HERRIG-025
Nombre de Postes : 1
Lieu de travail : MARSEILLE 13
Date de publication : vendredi 28 novembre 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 12 mois
Date d'embauche prévue : 2 février 2026
Quotité de travail : Complet
Rémunération : Between 3 132€ and 4 342€ gross monthly
Niveau d'études souhaité : Doctorat
Expérience souhaitée : 1 à 4 années
Section(s) CN : 08 - Micro et nanotechnologies, micro et nanosystèmes, photonique, électronique, électromagnétisme, énergie électrique
Missions
Histology is routinely performed in hospitals and involves taking a small tissue sample (biopsy), which is then sliced, stained, and examined by a specialist to diagnose its cancerous nature. This process is time-consuming (1–24 hours) and prevents optimal patient management during surgical procedures or endoscopic exploration. This postdoctoral research project aims to develop a completely novel optical technology for instantaneous three-dimensional histological imaging of biopsies, without the need for labeling or prior preparation.
The proposed approach uses wide-field coherent Raman imaging with random speckle field illumination to reconstruct a 3D z-stack image of the chemical bonds present in the sample, without any labeling or preparation. This method closely integrates the latest technological innovations in lasers, microscopy, and low-noise optical detection with advanced digital reconstruction techniques.
This postdoctoral research program will focus on theoretical aspects. The work will involve modeling speckle illuminations and nonlinear optical contrasts (two-photon fluorescence, SHG, CARS). The resilience of speckle illumination approaches in scattering media will also be investigated. Theoretical predictions will be compared with experimental results obtained by other team members.
Activités
The activity will involve carrying out the research program. This will include mathematically formalizing the illuminations and optical contrasts (both linear and nonlinear) and conducting numerical simulations. The results will be formatted for presentation.
Compétences
Applied mathematics
Electromagnetism
Numerical simulations
Data presentation
Contexte de travail
The project is being conducted as part of the ERC SpeckleCARS project:
https://www.fresnel.fr/wp/projet-europeen/erc-specklecars/
Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.
Contraintes et risques
None