En poursuivant votre navigation sur ce site, vous acceptez le dépôt de cookies dans votre navigateur. (En savoir plus)
Portail > Offres > Offre UMR7241-HERTUR-007 - H/F Post-doc modélisation biophysique des corps nucléaires PML

Biophysical modeling of PML nuclear condensates

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 3 février 2022

Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler. Les informations de votre profil complètent celles associées à chaque candidature. Afin d’augmenter votre visibilité sur notre Portail Emploi et ainsi permettre aux recruteurs de consulter votre profil candidat, vous avez la possibilité de déposer votre CV dans notre CVThèque en un clic !

Faites connaître cette offre !

General information

Reference : UMR7241-HERTUR-007
Workplace : PARIS 05
Date of publication : Thursday, December 23, 2021
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 14 February 2022
Proportion of work : Full time
Remuneration : between € 2,500 and € 2,800 gross monthly depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

This project aims to extend the theoretical framework of liquid-liquid phase transitions to describe the formation of liquid condensates with a core-shell architecture1 and their regulation by biochemical reactions. The research will focus on the growth and coarsening dynamics2 of PML nuclear bodies, which are stress-regulated membrane-less organelles controlling multiple biological functions in the nucleus, such as metabolism or senescence. It will be performed in the theoretical physics team Multiscale Physics of Morphogenesis led by Hervé Turlier, and in tight collaboration with the experimental biology team Nuclear Organization and post-translational control in physio-pathology led by Prof. H. De Thé & Dr. V. Lallemand at Collège de France, who are worldwide specialists of the biochemistry and cellular biology of PML, and its role in cancer.

Activities

The successful candidate will develop non-equilibrium physical models and numerical simulations of nuclear condensate dynamics, going beyond recent developments in the field of biological phase transitions. The work will also involve image analysis, and may include data analysis using on physics-informed deep learning techniques. She/he will work closely with biologists in the host Institute and will have daily interactions with other members of the team. She/he will have to present her/his results at scientific conferences, to write scientific articles and to actively participate in the scientific and social life of the team and host Institute.

Skills

The candidate should hold a PhD in theoretical physics and demonstrate very good analytical skills. She/he should have already demonstrated the ability to publish in international peer-reviewed scientific journals. Previous experience in physical modelling of biological phase transitions will be a strong asset, and a proved capacity to collaborate with biologists will be particularly appreciated. A great autonomy in work, and research initiative will be necessary. Proficiency in English and good communication skills are expected.

Work Context

The successful candidate will work in the interdisciplinary team "Multiscale physics of morphogenesis" led by Hervé Turlier composed of 10 scientists from various backgrounds (physics, applied mathematics, computer science, biology). The team is located at the Collège de France, in the heart of the Latin Quarter in Paris. Integrated within the PSL University, and close to other major institutions such as Ecole Normale Supérieure and Institut Curie, the Collège de France constitutes an exceptional and unique scientific environment in the world. The successful candidate will be provided an individual workstation in renovated premises, a powerful laptop and will have access to a high performance computing cluster (CPU+GPU) fully dedicated to the team.

Constraints and risks

N/A

We talk about it on Twitter!