Postdoct Positions in Systems Neuroscience (M/F)

Job Description

Missions

The mission of the candidate will be to develop the experimental tools to manipulate neuronal and vascular processes with optogenetics and learn electrophysiology and functional ultrasound imaging, to observe the effects of these manipulations at the whole brain scale. He/she will also contribute to develop the new research team and will work closely with the PI to validate the experimental designs, acquisition and analysis pipelines.

Activity

Experimental work:
• Surgical training for combined functional ultrasound and electrophysiology experiments
• Postoperative care, handling and well-being monitoring in rats and mice
• Acquisition of multimodal data in freely behaving rodents during behavioral tasks (contextual fear conditioning, T-maze)
• Design and validation of closed loop optogenetics stimulations on neural and vascular processes
• Collaborative work with team members and core facilities

Data analysis:
• Multimodal Data Analysis including behavior (Deeplabcut), electrophysiological data (sleep scoring, spike sorting) and fUSi data (image processing)
• Documentation, traceability, and archiving of analyses and experiments on open-source repositories (GitLab, Git, Wiki)
• Initiative and design in new analysis techniques, possibly involving neural networks.

Presentation and dissemination:
• Active involvement in team tasks and events
• Literature review and bibliography (journal club)
• Presentation in team meetings and international conferences
• Student/Intern mentoring, implication in hiring other team members
• Writing of scientific articles
• Grant writing (e. g. Marie Sklodowska-Curie actions)
• Contribution to open-source team projects and resource sharing

Your Profil

Skills

Required degree: PhD degree in Experimental Neuroscience.

Skills and Expertise:
• At least one first-author publication or preprint in neurophysiology or neuroimaging
• Experimental expertise in rodent neurophysiology (surgeries, behavioral tasks)
• Programming skills (Matlab or Python)
• Interdisciplinary background is a plus
• English proficiency (French is not required)
• Proven ability to write scientific articles, give oral presentations and conduct projects

Knowledge:
• Cognitive neuroscience and/or neurophysiology
• Basics in wave Physics (ultrasound, light, electromagnetism)
• Advanced Data analysis methods and Statistics
• Legal and ethical framework of animal experimentation

Personal qualities:
• Motivation and passion for neuroscience
• Autonomy and strong organizational skills
• Scientific curiosity
• Teamwork and communication skills
• Organizational skills
• Respect for ethical rules and regulatory obligations under the protocol

Your Work Environment

Host Institute: The Paris Brain Institute (CNRS UMR 7225, INSERM U1127, Sorbonne Universite UM75) is a private foundation recognized as being of public interest, whose purpose is fundamental and clinical research on the nervous system. At a single location, 950 researchers, engineers, and physicians cover all disciplines of neurology, with the aim of accelerating discoveries about brain function and the development of treatments for diseases such as Alzheimer's, Parkinson's, multiple sclerosis, epilepsy, depression, paraplegia, tetraplegia, etc.

Host Team: The MOVIT Team (Movement, Investigation, Therapeutics), led by Pierre Pouget and Emmanuel Flamand-Roze aims to investigate various aspects of motor and cognitive control, particularly inter and intra-subject variability in developmental and acquired disorders and in genetically related animal models. Within the team, Dr Antoine Bergel is an ATIP-Avenir Emerging Group Leader, looking to establish his independent research group in the coming years. He pioneered the development of functional ultrasound imaging coupled to electrophysiology (fUS-ephys) in freely moving rats, mice and reptiles. His lab will investigate the physiology of sleep, in particular rapid-eye-movement sleep, in relation with emotional memory and brain clearance processes using interdisciplinary approaches to understand and manipulate neurovascular processes at the whole-brain scale.

Compensation and benefits

Compensation

2800-3200 euros (monthly gross)

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions