Postdoctoral position in Mass Spectrometry (M/F)

Job Description

Missions

In the frame of an ANR project, the candidate will develop structural MS approaches (HDX-MS, mass photometry, native MS and cross-linking MS) for the characterization of mulitprotein complexes. The goal is to provide conformational and structural information to complement structural biology techniques.

Activity

- Design, perform and interpret mass photometry, native MS, HDX-MS and cross-linking MS on a series of mulitprotein complexes.
- Bioinformatics interpretation of data.
- Monitor project(s)
- participate and present results in consortium meetings.
- Write reports.
- Present, disseminate and promote achievements.
- Ensure traceability of analyses as part of LSMBO's quality approach (ISO9001 environment).

Your Profil

Skills

General knowledge :
- Advanced knowledge in bioanalytical chemistry, mass spectrometry-based protein analysis.

Operational know-how :
- In-depth knowledge in intact protein analysis using mass spectrometry
- Knowledge in nanoLC-MS/MS proteomic analysis;
- knowledge in HDX-MS and/or XL-MS (chemical crosslinking MS).
- Master liquid chromatography (reverse-phase chromatography) and tandem mass spectrometry techniques;
- Master specific tools and software for reprocessing mass spectrometry data (Dynamix, Proteome Discoverer, MaxQuant, etc.).
- Manage work in an ISO9001-certified environment;
- Communicate with internal and external contacts;
- Work as part of a team in a multidisciplinary environment;
- Communicate in english (written and spoken) so as to be able to make regular reports and present results to English-speaking colleagues.

Your Work Environment

The Institut Pluridisciplinaire Hubert CURIEN (IPHC), a joint research unit under the joint supervision of CNRS and the University of Strasbourg (UMR7178), is a multidisciplinary laboratory where research teams from different scientific cultures (ecology, physiology and ethology, chemistry and subatomic physics) develop very high level programs based on scientific instrumentation. The IPHC is structured into 4 departments and has a total staff of 393 staff including 257 permanent staff (ie 119 researchers and teachers / researchers and 138 engineers and technicians), 46 staff on fixed-term contracts and 102 doctoral students.

The Post-Doctoral researcher will be welcomed into the BioOrganic Mass Spectrometry (LSMBO) team of IPHC. The LSMBO is part of the IPHC's Department of Analytical Sciences (UMR7178, CNRS / Université de Strasbourg), and comprises around fifty permanent and non-permanent staff (researchers, engineers, PhD students, postodcs and student trainees).

The postdoctoral researcher will interact on a daily basis with all LSMBO staff, including mass spectrometry engineers, computer scientists and bioinformaticians. He/she will also interact with collaborators from outside the laboratory.

The recruited person will be placed under the responsibility of Sarah Cianferani
The candidate (M/F) will have access to a staff restaurant, partial reimbursement of transportation costs, a works council, the possibility of teleworking one to two days per week for some activities , subject to the agreement of the LSMBO team manager, and training to adapt to the job.

Constraints and risks

Work in an ISO 9001 certified environment

Compensation and benefits

Compensation

Between 3072 and 3502 euros gross monthly according to experience

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions