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Portail > Offres > Offre UMR7178-REGSOM-099 - H/F Postdoctorant-e en études de simulation d'un nouveau prototype de TEP

M/W PostDoc in simulation studies for a novel PET prototype

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 16 décembre 2021

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General information

Reference : UMR7178-REGSOM-099
Workplace : STRASBOURG
Date of publication : Thursday, November 25, 2021
Type of Contract : FTC Scientist
Contract Period : 10 months
Expected date of employment : 15 January 2022
Proportion of work : Full time
Remuneration : Between 2690.43 and 3821.07 euros gross monthly according to experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

The research project of this post-doctorate relies on the components simulation and instrumentation of new detectors of the host team's research activities:
- Set up the simulation for a new prototype of positron emission tomography (PET) scanner using LiquidO technology, the construction of which is scheduled for the end of 2022. Upon arrival, the candidate will be in charge of settng up the Monte-Carlo framework and the software architecture for the generation and processing of simulation data which will validate the feasibility of applying LiquidO technology to PET.
- Take an active part in decision-making during the instrumental development of the TEP-Otech system, within a consortium of 4 French laboratories, and linked to a wider collaboration for the development of LiquidO technology. The final decisions on the design of the instrument will be based on the results of the preliminary simulation studies carried out by the candidate.

Activities

- Setting up and analyzing Monte Carlo simulations,
- Deciding on the optimal materials and geometry for the development of the tomograph,
- Developing a reconstruction for the multiple interactions within the detector
- Estimating gamma tracks and detecting coincidences while minimizing backgrounds,
- Writting articles and advertising results at conferences and workshops in the field.

Skills

The applicant should have :
- A strong academic record (Master's degree or equivalent) and a PhD in experimental particle physics or ionizing radiation physics.
- A good knowledge of Monte Carlo simulations tools such as Geant 4 or GATE.
- An experience in working with liquid scintillator based detectors and analyzing data from such devices.
- An experience in event reconstruction and selection using machine learning tools.
- An experience in event reconstruction in Time Projection Chamber (TPC).
- A previous experience with the OTEch technology is a plus.
- Abilities for writting and speaking English level B2 according to the Common European Framework of Reference for Languages, in order to prepare scientific communications in international peer-reviewed journals, and advertise results in international conferences and workshops.
- The applicant should demonstrate a strong motivation to contribute to a multidisciplinary project, at the interface between particle physics and clinical imaging.

Work Context

- keywords : Molecular Imaging, instrumenta7on, detectors, liquid scintillator, photodetection, ortho-positronium, Monte Carlo simulation, data analysis, Artificial Intelligence

The IPHC, a joint research unit under the joint supervision of CNRS and the University of Strasbourg (UMR7178), is a multidisciplinary laboratory where research teams from different scientific cultures (ecology, physiology and ethology, chemistry and subatomic physics) develop very high level programs based on scientific instrumentation. The IPHC is structured into 4 departments and has a total staff of 393 staff including 257 permanent staff (ie 119 researchers and teachers / researchers and 138 IT), 46 staff on fixed-term contracts and 90 doctoral students.

The Post-Doctoral researcher will be welcomed into the molecular imaging team which includes 5 researchers, 10 engineers and 3 doctoral students. The person recruited will be placed under the responsibility of David Brasse.
The IPHC's molecular imaging team is helping to improve ionizing radiation detection modules.
At the crossroads of physics, chemistry, biology and medicine, the molecular imaging team participates in many multidisciplinary programs, making biomedical imaging a powerful technology at the service of humans.
The group's activities are organized around two main research axes. First, the group offers all the expertise necessary for instrumental development in the field of imaging, and more particularly"nuclear" imaging modalities such as PET and TEMP. These developments include the design of complete acquisition systems (electronic boards, ASICs, FPGAs, etc.) as well as the development of detection modules with particular expertise in scintillating crystals and photo-detectors.
The second major area of research of the group is radiochemistry, in other words the labeling of molecules (antibodies, peptides, macro- and small molecules) with various isotopes dedicated to PET and TEMP imaging. The presence of the Cyrcé cyclotron is a major asset in this field thanks to the production of various isotopes. This expertise in radiochemistry goes hand in hand with the data analysis and quantification processes. In addition, the presence of a level 2 animal accommodation center gives the group perfect autonomy to carry out research projects in preclinical imaging.
The real qualitative leaps made in recent years in nuclear imaging are most often linked to decisive advances in technology. In clinical positron emission tomography, the current challenges are in time-of-flight (TOF) measurement and bimodal PET / MRI imaging. These two axes are closely linked to the performance of detection modules and more particularly to the scintillating crystal / photodetector pair used and to the associated reading electronics.
Time-of-flight measurement is the preferred option today for increasing the signal-to-noise ratio in the reconstructed image.
An alternative to standard PET acquisition is the use of γ-β + isotopes such as 22Na or 44Sc. The use of the 3γ acquisition allows us to foresee an improvement in the TOF information. Indeed, the detection of the additional γ prompt allows us to further constrain the reconstruction of the origin of the annihilation.
The contribution of the tools and methods developed within the framework of artificial intelligence combined with the improvement of the technologies used for the detection of ionizing radiation opens up promising perspectives in the improvement of performance in PET imaging.
A post doctoral researcher position is open in the group over a period of 10 months to participate in the ANR TEP-OTEch program and set up the tools and methods for Monte-Carlo simulation and reconstruction of interactions in the TEP-OTEch prototype.
The successful applicant will not work on restricted access area (ZRR).

Constraints and risks

Short trips are to be expected in France and abroad for carrying out the experiments and presenting the results at conferences.

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